Self-replicating RNA derived from the genomes of positive strand RNA viruses represents a powerful tool for both molecular studies on virus biology and approaches to novel safe and effective...Tews, Birke AndreaFederal Research Institute for Animal HealthMeyers, Gregor...
self-replicating 英['selfr'eplɪkeɪtɪŋ] 美['selfr'eplɪkeɪtɪŋ] 释义 adj. 自我复制的 实用场景例句 全部 The closest real things to these creatures were bits of self - replicating RNA. 最贴近这些造物的实物是能做一点微不足道的自复制的核糖核酸. 互联网 Our problem, then...
Biebricher CK (1983) Darwinian selection of self-replicating RNA molecules. In: Hecht MK, Wallace B, Prance GT (eds) Evolutionary biology, vol 16. Plenum Press, New York, pp 1–52Biebricher, C. K. 1983. Darwinian selection of self-repli- cating RNA molecules. Evolutionary Biology 16:1-...
Self-replicatingrobots are no longer the stuff of science fiction. 自此,可自我复制的机器人不再是科幻小说中才会有的情节素材。 3. The closest real things to these creatures were bits ofself-replicatingRNA. 最贴近这些造物的实物是能做一点微不足道的自复制的核糖核酸。
Naked, non-infectious, self-replicating RNA may be an excellent candidate for the development of new cancer vaccines.YingHanZaksTalZ.WangRong-FuIrvineKariR.EBSCO_AspNature MedicineYing, H., T. Z. Zaks, R. F. Wang, K. R. Irvine, U. S. Kammula, F. M. Marincola, W. W. Leitner, ...
The self-replicating RNA vectors did not mediate the production of substantially more model antigen than a conventional DNA vaccine did in vitro. However, the enhanced efficacy in vivo correlated with a caspase-dependent apoptotic death in transfected cells. This death facilitated the uptake of ...
Recently, self-replicating and self-limiting RNA vaccines (RNA replicons) have emerged as an important form of nucleic acid vaccines. Self-replicating RNA eventually causes lysis of transfected cells and does not raise the concern associated with naked DNA vaccines of integration into the host genom...
“At ASCO 2024, we are excited to present the interim clinical data of our JCXH-211 trial. JCXH-211 is a first-in-class interleukin-12 (IL-12) therapeutic using a novel self-replicating RNA (srRNA) drug modality,” said NgocDiep Le, M.D., Ph.D., President and Global CMO. “JCX...
“JCXH-105 has been developed using Immorna’s propriety srRNA platform, which features improved immunogenicity and reactogenicity compared to the standard alphavirus RNA replicon. We chose to use srRNA because compared to the non-replicating conventional mRNA, srRNA strongly modulates T cell ...
Self-replication of the RNA variant MNV-11 (86 base-pairs) by Qβ replicase leads, in the presence of salt, to stepwise selection of the more salt-resistant variants SV-11 (113 base-pairs) and MDV-1 (220 base-pairs). The structures of these and two other unrelated salt-resistant varia...