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Aims: Achieving an effective biocompatible system for siRNAs delivery to the tumor site remains a significant challenge. Materials & methods: Selenium nanoparticles (SeNPs) modified by chitosan (CS) and hyaluronic acid (HA) were fabricated for PLK1 siRNAs (siPLK1) delivery to the bladder cancer ...
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study, the NCh was loaded to improve the biological properties of the biosynthesized SeNPs [126]. The biosynthesized SeNPs and Se/Ch-nanoconjugate exhibited outstanding anticancer activity against HepG2 and Caki-1 (HTB-46) tumor cell lines; the nanoconjugate was the most powerful with IC50...
This can lead to improved material properties, such as increased stability, higher melting points, and enhanced optical or electrical properties, compared to amorphous materials with a disordered structure.[34] Stability The stability of SeNPs and TP-SeNPs was investigated under pH 8 at 4°C and...
Of interest is that low serum Se (<0.75 µM) is associated with the downregulation of sirtuin concentration in peripheral blood mononuclear cells [156]. 5.3. Se Plasma Concentration, Skin Disorders and Supplementation A study on the different European countries reported values of mean intake in...
Materials are considered nanomaterials (NMs) when at least one of the dimensions measures less than 100 nm. NMs also possess a large area per unit of volume. Indeed, NMs are defined as those materials with an area/volume ratio over 60 m2/cm3[1]. Given this high specific area per unit ...