Beta-1 receptors are mainly found in the cardiac tissues and kidneys. Selective beta-1-blockers bind to the beta-1 receptor sites and inhibit the action of hormones norepinephrine andepinephrine. Norepinephrine and epinephrine are the hormones that are produced by theadrenal glandand also by the ...
Omerovic E, Bollano E, Mobini R, et al. Selective beta(1)-blockade improves cardiac bioenergetics and function and decreases neuroendocrine activation in rats during early postinfarct remodeling. Biochem Biophys Res Commun 2001;281:491-8.
Overall, the majority of beta‐1 blockers studied significantly lowered systolic blood pressure (SBP) and diastolic blood pressure (DBP). In people with mild to moderate hypertension, beta‐1 selective blockers lowered BP by an average of ‐10/‐8 mmHg and reduced heart rate by 11 beats per...
beta-Blockers, particularly propranolol, have been shown to be an effective treatment for neuroleptic-induced akathisia (NIA). To examine the relative contribution of beta-1 and beta-2 receptor blockade to the therapeutic effect of propranolol, we studied a beta-1 selective agent (low dose meto...
ASL-8052 is a new cardioselective ultra-short-acting beta blocker which allows abolition of beta blockade within 16 minutes on termination of an intravenous infusion. An investigation was made of the effect of ASL-8052 on myocardial ... R Lange,RA Kloner,E Braunwald - 《American Journal of ...
However, on digitalis arrhythmia, both beta blockers were ineffective, even though the high doses used in these experiments, 3 mg/kg for betaxolol and 5 mg/kg for atenolol, showed significant hypotensive effects. The present results suggest that betaxolol and atenolol may be expected to be ...
摘要: Hydroxyalkyl-phenoxy-propan-2-ol-3-amines are oculoselective beta -blockers useful in the treatment of elevated intraocular pressure with little or no effect on the pulmonary or cardiovascular system. <CHEM> o收藏 引用 批量引用 报错 分享 ...
Cardioselective ß blockers are not associated with increased respiratory symptoms or inhaler use in patients with COPD or reactive airway disease and are associated with an augmented FEV1 response after ß-2 agonists compared with placebo. Conversely, ß-2-agonist use is associated with the de...
1-Selective Blocker, on Endotracheal Intubation in Patients With and Without Hypertension BACKGROUND: Occasionally it is difficult to inhibit electrical storm (ES) with standard pharmacological treatment. In the present study the effect of landiolol, an ultra-short-acting beta(1)-selective blocker, ...
Selective determination of some beta-blockers in urine and plasma samples using continuous flow membrane microextraction coupled with high performance liquid chromatographyBeta-blocker drugsBody fluidMembrane microextractionOnline analysisSelective determination...