In addition to informing evolutionary hypotheses of adaptation, the discovery and functional annotation of adaptive alleles also may be of clinical significance. While selection mapping efforts in non-European populations are growing, there remains a stark under-representation of diverse human populations ...
The identification of signals of very recent positive selection provides information about the adaptation of modern humans to local conditions. We report here on a genome-wide scan for signals of very recent positive selection in favor of variants that have not yet reached fixation. We describe a...
and this simple process remains the central explanation for all evolutionary adaptation yet today. Positive selection is by no means the only component of evolution, however. In humans, at least, the great
Evolution - Natural Selection, Adaptation, Genetics: The central argument of Darwin’s theory of evolution starts with the existence of hereditary variation. Experience with animal and plant breeding had demonstrated to Darwin that variations can be deve
Selection might have been more important in shaping patterns of variation in the genome than was previously anticipated, although the relative importance of background selection and genetic hitchhiking remains unknown. Most strategies that are used to detect whether natural selection has affected a specif...
Function of Cytochrome P450s and Gut Microbiome in Biopesticide Adaptation of Grapholita molesta on Different Host Diets Insects that feed on various host plants possess diverse xenobiotic adaptations; however, the underlying mechanisms are poorly understood. In the present s... Y Liu,J Yu,F Zhu,...
Right now, the signaling mechanisms that wire up the 100 billion cells in the human brain are something of a mystery. How can the mere 60,000 genes in the human genome tell 100 billion neurons how to precisely wire themselves in the human brain? No one right now has a clear understanding...
represented by the fact that I can just about draw a straight line between these points,Natural Selection will occurand it willpush the trait to the right. This situationproduces adaptation, it produces all of the fantastic biology that you're familiar with. It's produced meiosis; it's produ...
Adaptation Heritable changes in genotype or phenotype that result in increased fitness. Fitness A measure of the capacity of an organism to survive and reproduce. Effective population size (Ne) The size of a population measured by the expected effect (through genetic drift) of the population size...
Adaptation and selection shape clonal evolution of tumors during residual disease and recurrence Andrea Walens, Jiaxing Lin, Jeffrey S. Damrauer, Brock McKinney, Ryan Lupo, Rachel Newcomb, Douglas B. Fox, Nathaniel W. Mabe, Jeremy Gresham, Zhecheng Sheng, Alexander B. Sibley, ...