SEL1L-HRD1对STING的ERAD作用不仅限于巨噬细胞,因为STING蛋白在Hrd1-/-小鼠胚胎成纤维细胞(MEFs)中也是在基础状态下稳定的(图3f)。因此,SEL1L-HRD1 ERAD-STING轴可能代表一种普遍的机制。 为了进一步证明SEL1L-HRD1 ERAD在STING生物学...
The SEL1L-HRD1 protein complex represents the most conserved branch of endoplasmic reticulum (ER)-associated degradation (ERAD). Despite recent advances in both mouse models and humans, in vivo evidence for the importance of SEL1L in the ERAD complex formation and its (patho-)physiological ...
The SEL1L-HRD1 protein complex represents the most conserved branch of endoplasmic reticulum (ER)-associated degradation (ERAD). Despite recent advances in both mouse models and humans, in vivo evidence for the importance of SEL1L in the ERAD complex formation and its (patho-)physiological relevan...
Indeed, SEL1L-HRD1 ERAD attenuates the biogenesis of GPI-anchored proteins by specifically targeting PIGK for proteasomal degradation. Lastly, several PIGK disease variants in inherited GPI deficiency disorders are also SEL1L-HRD1 ERAD substrates. This study provides a platform and resources for ...
The pre-BCR complex accumulates both intracellularly and at the cell surface in Sel1L-deficient pre-B cells, leading to persistent pre-BCR signaling and pre-B cell proliferation. This study thus implicates ERAD mediated by Sel1L-Hrd1 as a key regulator of B cell development and reveals the ...
Indeed, ANGPTL3 is a bona fide endogenous substrate of SEL1L-HRD1 ERAD in the liver and in the absence of ERAD, ANGPTL3 protein is retained in the ER, forming high-molecular weight aggregates. This abnormal ER retention of ANGPTL3 accounts for a reduced circulating level of ANGPTL3, ...
Regulation of Podocyte Adhesion by SEL1L-HRD1 ERAD via Integrindoi:10.1681/ASN.20233411S1305aXiaoqiong WeiYou LuLing QiAmerican Society of NephrologyJournal of the American Society of Nephrology
Recent studies using cell type–specific knockout mouse models have improved our understanding of the pathophysiological relevance of suppressor of lin-12-like–HMG-CoA reductase degradation 1 (SEL1L-HRD1) endoplasmic reticulum–associated (ER-associated) degradation (ERAD); however, its importance in...
Innate immunityJi et al. report that under basal conditions the SEL1L–HRD1 complex for endoplasmic reticulum-associated degradation ubiquitinates and negatively regulates STING protein levels in the endoplasmic reticulum, hence its activation.doi:10.1038/s41556-023-01138-4Yewei,Ji...
SEL1L and HRD1 are involved in the degradation of unassembled secretory Ig-mu chains. J Cell Physiol . 2008;215:794–802. : 10.1002/jcp.21364 .Cattaneo M, Otsu M, Fagioli C et al. SEL1L and HRD1 are involved in the degradation of unassembled secretory Ig-mu chains. J Cell Physiol ...