Sel1-like repeatsTerminally misfolded or unassembled proteins are selectively recognized and cleared by the ER-associated degradation (ERAD) pathway. Suppressor/enhancer of lin-12-like (SEL1L), a component of the dislocation machinery containing the E3 ubiquitin ligase Hrd1, plays an important role ...
Sel1-like repeats (SLR)Hof1Chs4Chs3Chs2chitinseptum formationbudding yeastLocalized extracellular matrix (ECM) remodeling, which mainly involves synthesis and breakdown of specific polysaccharides, is important for cytokinesis and celdoi:10.2139/ssrn.3151995Oh, Younghoon...
Sel-1L2 (suppressor of lin-12-like protein 2) is a 688 amino acid single-pass type I membrane protein that contains eleven Sel1-like repeats and belongs to the Sel-1 family. The gene encoding Sel-1L2 maps to human chromosome 20, which comprises approximately 2% of the human genome and...
SP, signal peptide; FNII, fibronectin type II domain; SLR-N/M/C, Sel1-like repeats at N-, Middle- and C-terminal; TM, transmembrane. b Amino acid sequence alignment of SEL1L showing the conservation of SEL1L S658 residue across species (highlighted in green). c Structural prediction of...
On the other hand, the protein kinase RNA-like ER kinase (PERK)-eIF2α branch of the UPR is not required for B cell differentiation (Zhang et al., 2005). Therefore, Sel1L-Hrd1 ERAD manages B cell development in an UPR-independent manner. Polypeptides that do not meet the quality ...