Seizure-related activity has been reported in many of these Mecp2 models, but with somewhat differing outcomes depending on mutation type and genetic background. The majority of work conducted to date has focused on either the Mecp2tm1.1Bird mouse strain (both males and females), which ...
Young females were stimulated throughout at 2.0 mA. Young males were initially stimulated at 1.6 mA. After 9 stimulations sessions, when young male WT mice were clearly experiencing focal seizures and KO males were not, the stimulation current for young PSEN2 KO males was increased to 3.0 mA....
NOS among adults are prevalent in elder males. CVDs are the most commonly identified etiology of adult NOS across males and females. Idiopathic epilepsy syndromes are the predominant etiology among younger adults.doi:10.1186/s41983-021-00349-6Mahmoud Hemeida Mahmoud...
Sex differences in sensitivity to seizures elicited by intraperitoneally injected pentylenetetrazol (PTZ) were studied in 240 (120 males and 120 females) adult Swiss mice. Animals were separated into four groups according to the dose that was injected: 40, 50, 60 and 70 mg/kg. Seizure severity...
Depressive disorders are the most common form of mental illness in America, affecting females twice as often as males. The great variability of symptoms an... TL Bale - 《Hormones & Behavior》 被引量: 409发表: 2006年 Prenatal maternal stress exposure and immune function in the offspring. 《...
Among the 147 autopsy cases studied, 80 were males and 67 were females, with the corrected age range spanning from 19GW (i.e. −21 weeks) to 20.4 years (i.e. +1060 weeks). Post-mortem interval (PMI) ranged from 2 to 336 h. Histological assessment of GCD...
Fig. 1:ASH1Lexpression and H3K4me3 level are significantly decreased in PFC of postmortem ASD patients, which is replicated by knockdown ofAsh1Lin PFC of young mice. aQuantitative PCR data showingASH1LmRNA levels in postmortem PFC tissues from control humans vs. idiopathic ASD patients.n = ...
To resolve the controversy surrounding the lateralizing value of ictal head deviation, we analyzed head-turning movements in relation to the actions of the two divisions of the sternocleidomastoid muscle. In 12 (75%) of 16 patients with surgically confirmed lateralized seizure foci, the face rotate...
Further studies should center in adjusting the parameters to elicit efficacy in females during adolescence. Highlights: There are clear sex and age differences in the antidepressant-like effects of ECS. Low dose intensities of ECS exerted antidepressant-like effects in adult female rats. ECS, at ...
While no Cacna2d2 expression was detected in mouse embryonic heart, previous reports indicated that this gene is highly expressed in both mouse and human adult hearts.8, 9, 10 Indeed, using the RT-PCR assay we demonstrated that the CACNA2D2 mRNA is expressed mainly in four cardiac ...