2009. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 139:485-498.Ivanov, I. I., Atarashi, K., Manel, N. et al. 2009. Induction of intes- tinal Th17 cells by segmented filamentous bacteria. Cell 139:485....
The systemic deficiencies of the GF animals reflected a loss of Th17 cells from the small intestinal lamina propria. Introduction of a single gut-residing species, segmented filamentous bacteria, into GF animals reinstated the lamina propria Th17 cell compartment and production of autoantibodies, and ...
In mice, colonization with segmented filamentous bacteria (SFB) induces T-helper-17 (Th17) cell differentiation in the intestine, yet the effector functions of interleukin (IL)-17A in response to SFB remain incompletely understood. Here we report that colonization of mice with SFB-containing ...
With the goal of identifying such interactions, we compared the composition of microbiota of Taconic and Jackson B6 mice.5We aimed to identify Th17 cell-inducing commensal bacteria and therefore concentrated on bacterial taxons that were overrepresented in the Taconic microbiota. Notably, the difference...
Induction of intestinal Th17 cells by segmented filamentous bacteria. The Key Role of Segmented Filamentous Bacteria in the Coordinated Maturation of Gut Helper T Cell Responses The Crucible within: Ethnic Identity, Self-Esteem, and Segmented Assimilation among Children of Immigrants ...
Segmented filamentous bacteria (SFB) are well known for their functions in the immunoregulation of hosts including the promotion of Th17 cell differentiation, B cell maturation, and immune system development. However, most analyses of SFB have focused on animal models, and thus, investigation of ...
Segmented filamentous bacteria (SFB) are commensal bacteria that preferentially colonize the ileum, mainly over PPs. SFB colonization of germ-free mice induces polyclonal IgA responses by unclear mechanisms. Using scmRNAseq and flow cytometry we found SFB colonization of SPF mice induced an increase ...
Interestingly, SIBO is also found in about 25% of patients with Crohn's disease.Emerging data show that specific components of gut microbiota, particularly segmented filamentous bacteria (SFB), activate intestinal immunocompetent cells, for example, Th17 cells which have a potential role in ...
2014. Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation. Immunity 40:594-607.Goto, Y. et al. Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation. Immunity 40, 594-607...
Herein, systematic analysis of gnotobiotic mice indicated that colonization by a whole mouse microbiota orchestrated a broad spectrum of proinflammatory T helper 1 (Th1), Th17, and regulatory T cell responses whereas most tested complex microbiota and individual bacteria failed to efficient...