Altogether, our results show a consistent pathophysiological effect of APOE4 on neurovascular function during times of greater neuronal activity, which is worsened by a sedentary lifestyle. These effects are seen in reductions in net hemodynamic measures, in individual arteries’ and capillaries’ dilati...
Sedentary Lifestyle Statistics Americans spend more than70 percent of time awakeeach day sitting. How does not moving regularly take a toll on our health? The World Health Organizationestimatesthat a lack of physical activity is associated with 3.2 million deaths a year. ...
Genetic correlations of self-reported LST and MVPA with objective, accelerometry-assessed daily physical activity traits in UK Biobank range from 0.14 to 0.44 (Fig.1b). Importantly, five of the eight loci previously identified for objectively assessed daily physical activity in UK Biobank data13,14...
Instruments used for the two-sample univariable MR analyses between sedentary behaviours and CAD can be found in Supplementary Data9. The instruments for the main analyses (P < 1 × 10−8) had F-statistics ranging from 29 to 164 for television watching, from 31 to 83 for computer...
ML approaches can potentially be a better analytical tool for examining the potentially interdependent relationships among diet, lifestyle behaviors, physical activity, sedentary and sleep behaviors—a scenario where ML approaches can potentially be a better analytical tool. An illustrative case is seen ...
S2 clearly showed that in UK Biobank cohort, the cumulative mortality risk associated with all-cause and four specific causes increased with increasing SB time, and the survival curves did not intersect among the three categories of sedentary time. Distinct demographic characteristics and lifestyle ...
Revenge of the “sit” II: Does lifestyle impact neuronal and cognitive health through distinct mechanisms associated with sedentary behavior and physical activity? Ment Health Phys Act. 2014;7(1):9–24. Article Google Scholar Hutton JS, Dudley J, Horowitz-Kraus T, DeWitt T, Holland SK. ...
An excellent example of how sedentary life can breed deleterious effects was seen during the COVID-19 lockdown, where individuals stayed at home, which induced less movement and physical activity, and this fact led to negative consequences in well-being.44 Besides the health consequences, some ...
www.nature.com/scientificreports OPEN received: 02 November 2016 accepted: 28 February 2017 Published: 31 March 2017 Sedentary lifestyle related exosomal release of Hotair from gluteal-femoral fat promotes intestinal cell proliferation Xiaozhao Lu1,2,3,*, Danna Bai3,4,*, Xiangwei Liu1,2,...
Kokko K, Fadjukoff P, Reinilä E, Ahola J, Kauppinen M, Kinnunen M-L et al. Developmental perspectives on transitions at age 60: individuals navigating across the lifespan (TRAILS)—Latest data collection in a longitudinal JYLS study [Manuscript submitted for publication]. Pulkkinen L, Fy...