Second generation antihistamines are recognised as being highly effective treatments for allergy-based disease and are among the most frequently prescribed and safest drugs in the world. However, consideration o
However, ebastine and epinastine did not show 50% [3H]-mepyramine binding inhibition even at 100 mg/kg orally In conclusion, ebastine was shown to be a potent and long-lasting H1-antihistamine with less effect to the CNS. Consequently, in conjunction the two experimental models used in this ...
WangXYLim-JuradoMPrepageranNTantilipikornPWang deYTreatment of allergic rhinitis and urticaria: a review of the newest antihistamine drug bilastineTher Clin Risk Manag20161258559727110120 (Open in a new window)PubMed (Open in a new window)Web of Science ®(Open in a new window)Google Scholar ...
The long duration of action of the second generation antihistamine bilastine coincides with its long residence time at the histamine H1 receptor Eur J Pharmacol (2018) BossV et al. Histamine induces nuclear factor of activated T cell-mediated transcription and cyclosporin A-sensitive interleukin-8 mR...