MCE 站:SDZ NKT 343 产品活性:SDZ NKT 343 是一种选择性的、具有口服活性的 NK1 receptor 拮抗剂,对人 NK1 受体的 IC50 为0.62 nM。SDZ NKT 343 具有良好的镇痛活性。 研究领域:GPCR/G Protein | Neuronal Signaling 作用靶点:Neurokinin Receptor In Vitro: SDZ NKT 343 shows a markedly lower affinity ...
Walpole CSJ, Brown MCS, James IF, Campbell EA, McIntyre P, Docherty R, Ko S, Hedley L, Ewan S, Buchheit KH, Urban LA (1998) Comparative, general pharmacology of SDZ NKT 343, a novel, selective NK 1 receptor antagonist. Br J Pharmacol 124:83–92...
Rees H, Sluka KA, Urban L, Walpole CJ, Willis WD. The effects of SDZ NKT 343, a potent NK1 receptor antagonist, on cutaneous responses of primate spinothalamic tract neurones sensitized by intradermal capsaicin injection. Exp Brain Res 1998;121:355-8....