Since the blood pharmacokinetic of SDZ PSC 833 was found to be linear in the dosage range studied, these results demonstrated a non-linear brain penetration of SDZ PSC 833. The brain passage of cyclosporin A was also found to obey a non-linear kinetic. However the potency of SDZ PSC 833 ...
99mTc-Sestamibi scanning with SDZ PSC 833 as a functional detection method for resistance modulation in patients with solid tumours. Our aim was to determine the value of 99mTc-Sestamibi scanning as functional detection method of P-glycoprotein (Pgp) blockade by PSC 833 in solid tumour p... M...
Lemaire,M.,Bruelisauer,A.,Guntz,P.,Sato,H.Dose-dependent brain penetration of SDZ PSC 833, a novel multidrug resistance-reversing cyclosporin, in rats.Cancer Chemotherapy and Pharmacology. 1996Lemaire, M. , Bruelisauer, A. , Guntz, P. and Sato, H. , Dose-dependent brain penetration of ...
SDZ PSC 833 (PSC 833) is a new multidrug resistance modulator. Recent studies have shown that the principal mechanism of action of PSC 833 is to bind P-glycoprotein (P-gp) and prevent cellular efflux of chemotherapeutic drugs. We previously reported that PSC 833 increases cellular ceramide ...
SDZ-PSC833维拉帕米逆转作用This article discusses the characteristics of the drugresistant human cervical carcinoma cell line HeLa/MMC and investigates reversal effect of SDZ-PSC833(PSC833) and Verapamil (Ver) upon HeLa/MMC. Relative content of cell DNA detection, H^3-TdR incorporation test and...
Then the volume of cancer, tumor weight, curve line of growing up in tumor -bearing nude mouse and its morphological variation of carcinoma organism are observed to evaluate the reversal effect of PSC833 and VER. It has been found that: ① Compared with HeLa cells,subline HeLa/ MMC Cells'...
Then the volume of cancer, tumor weight, curve line of growing up in tumor -bearing nude mouse and its morphological variation of carcinoma organism are observed to evaluate the reversal effect of PSC833 and VER. It has been found that: ① Compared with HeLa cells,subline HeLa/ MMC Cells'...
结果 顺铂联用Verapamil或SDZ PSC833可提高细胞生长抑制率;顺铂引起S期细胞比例增高,大剂量顺铂造成期细胞大量凋亡;doi:CNKI:SUN:ZZLL.0.2000-02-006廖美焱湖北医科大学附二医院陈惠祯武汉大学中南医院肿瘤廖美焱,陈惠祯,杨庆忆,邱慧玲,刘诗权,候流英.顺铂及增敏剂Verapamil、SDZ PSC 833诱导卵巢癌细胞凋亡的研究[...
Forty-two patients with advanced solid tumors were entered into a dose-finding study of the combination of doxorubicin with the cyclosporin analogue SDZ PSC 833 (PSC), given by oral route. Patients received PSC at escalating doses, ranging from 2.5 to 25 mg/kg/day, for 5 days, in doses...
Reversal of typical multidrug resistance by cyclosporin and its non-immuno- suppressive analogue SDZ PSC 833 in Chinese hamster ovary cells expressing mdr1 phenotype. Cancer Chemother. Pharmacol. 1992, 30, 238-342.Peter A. W. Boekhorst,Jan Kapel,Martijn Schoester,Pieter Sonneveld. Reversal of ...