Nephron mass vs nephron function. It is generally accepted that 75% of nephron mass must be lost before sCr increases above the reference limit (Braun, et al., 2003). The original source for this statement likely originates from partial nephrectomy studies in dogs. However, it is often mista...
6. Craig AJ, Sequela J, Queau Y, Murgier P, Concordet D, Fleeman LM, Mimouni P, Braun JP, Germain C, Lefebvre HP (2006): Redefining the reference interval for plasma creatinine in dogs: effect of a ge, gender, body weight and breed. Journal of Veterinary Internal Medicine 20, 74...