Baseline plasma levels of ADMA, SDMA, AcADMA, AcSDMA, and LNMMA were measured by liquid chromatography鈥攖andem mass spectrometry. All patients were followed annually for CKD progression and for incident atherosclerotic cardiovascular events.Results During 5.1卤2.1years follow-up, 80 patients ...
从生成代谢来看,SDMA是所有动物体内都存在的物质,SDMA水解后主要有三个种类的甲基精氨酸:单甲基精氨酸(MMA)、不对称二甲基精氨酸(ADMA)和对称性二甲基精氨酸(SDMA)。虽然三者通过不同的方式排出体外,但我们明确知道ADMA和SDMA的体内产生是串联的,(引用17)我们还知道有不少情况会造成ADMA的上升——进而SDMA也会跟...
Biological MMA, ADMA and SDMA occur as free acids in the nM-range and as residues of proteins of largely unknown quantity. Arginine:glycine amidinotransferase (AGAT) catalyzes the synthesis of L-homoarginine (hArg) from free Arg andl-lysine. Biological hArg is considered to occur exclusively ...