经国家自然科学基金委员会监督委员会六届二次会议审议、国家自然科学基金委员会2023年第21次委务会议审定,决定依据《国家自然科学基金项目科研不端行为调查处理办法》第四十四条第一项和第四项、第五十条第二款,取消季节国家自然科学基金项...
Inflammation-induced oxidative stress is a key mediator of myocarditis progression [70]. In our study, MCC950 downregulated the expression of ROS and CaMKII and the rate of arrhythmogenesis in the RVOTs of rats with myocarditis. These findings suggest that the activation of NLRP3-induced CaMKII...
Early intervention in candidates with early-stage CKD may delay, or avert, progression to end-stage complications. It is widely accepted that serum Cystatin C is a reliable and early indicator of CKD. Urinary Cystatin C tends to increase with the progression of kidney malfunctioning. Thus, early...
Although TH proteins showed no difference in the early stage of MP mice and the PT320-treated groups, there was a significant difference in cytochrome c release and ROS production at 8 weeks of age, indicating a potential molecular change during the early stage of disease progression. A Cytochr...
Besides, the chest CT scan is suggested to be able to detect COVID-19 in the early stage, especially useful for screening asymptomatic patients or patients with negative NAT results [8]. More importantly, signs of disease progression can also be observed from chest CT images, and as reported...
In ‘lab challenges,’ players who have completed Eterna’s progression of game-teaching RNA tutorial puzzles for new users submit RNA puzzle ‘solutions’ and select a subset of these by voting, which then is synthesized and tested in research labs. Players share design strategies and help ...
(Fig.2c). Yet, in some regions of the Swiss plateau, the pattern was more scattered than it was for the former two species. The seasonal progression of observation probability at a few selected locations indicates that this scattering results from double peaks in observation probability: on ...
Such strategy should not penalize overall survival, provided resuming immunotherapy at disease progression before second-line platinum-based chemotherapy. Trial design This is an open-label, randomized, phase III study in adult (≥18 years) patients, with stage IV non-small cell lung cancer, PD-...
Patients with stage III/IV ALK-positive NSCLC were randomized to receive twice-daily alectinib 600 mg (n = 152) or crizotinib 250 mg (n = 151) until disease progression, toxicity, withdrawal or death. Primary end point: investigator-assessed PFS. Secondary end points included objective response...
In this study, we showed that a cell cycle gene, RCC2, is a potential downstream target of the PI3K pathway, which has been shown to play a role in glioma progression. RCC2, also known as TD-60, was first identified as a novel human mitosis-specific autoantigen that localizes at the...