A: active; AP: acute pyelonephritis; BV: bacterial vaginosis; CAP: community-acquired pneumonia; CC: chemical class; cIAI: complicated intraabdominal infections; CRE: carbapenem-resistant Enterobacterales; cSSTI: complicated skin and soft tissue infections; cUTI: complicated urinary tract infection; G...
These compounds were formed by conjugation of a-CH2-heteroaryl group to the amine of Amt (Fig. 3E and F, IC50 of 16 μM) and inhibited S31N with potencies greater than Amt against AM2 (Wang, Wu, et al., 2013). The charged ammonium binds as a hydrate to one of three sites ...
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On the first day of class, I will introduce students to two large scale datasets. Students will use these data for applied examples over the 10 days of the course. The remaining portion of class (approximately 1.5-2 hours) will be devoted to hands on learning with R, simulated data, and...
Many applications of laser-driven ion sources require a transition from single-shot proof-of-principle studies to sustainable repetitive operation. The requirement of high repetition rate (>Hz) currently necessitates the use of femtosecond-class high-power laser drivers, which can provide high intensit...
9 CO2Me N Ts +N RH 10 R= -(CH2)nOAc, n = 3-5 R= -(CH2)4CH4 R= -(CH2)3CH(CH2OAc)2 R= -(CH2)nCO2Me, n = 2 or 4 O O R HN MeO CO2Me viii O O R HN HO CO2Me N Ts 11 N 12 Ts O ix O CO2H R' HN HO N H R'= -(CH2)nOH, n = 3, D-410637; n =...
The DOSnet proposed by Fung et al.202 (Fig. 3b) uses the electronic DOS spectra calculated from DFT as inputs to a CNN model to predict the adsorption energies of H, C, N, O, S and their hydrogenated counterparts, CH, CH2, CH3, NH, OH, and SH, on bimetallic alloy surfaces. ...
(comprising DUSP1/2/4/5 or MKP-1, PAC-1, MKP-2, and hVH3 respectively), the cytoplasmic MKPs (comprising DUSP6/7/9 or MKP-3, MKP-X, and MKP-4 respectively, which have biased preference over ERK1/2 inactivation), as well as the last class with biased specificity towards JNK/...
b) Difference in -CH2 and 14u molecular mass c) Gradation in physical properties d) Same functional group 4. Why does the Sun appear white at noon? 5. Both a spherical mirror and a thin spherical lens have a focal length of (-)15 cm. What type of mirror and lens are ...
The kinetics of decomposition of the organo-thallic adduct formed in methanol between styrene and Tl(OAc)3, (C6H5—CH(OCH3)—CH2—Tl(OAc)2) has been studied in a water–methanol solvent. The reaction follows a first order rate law. The organo-thallic compound, RTl(OAc)2, is shown ...