On testis sections, which contain both SGC and seminolipid, the SGC-positive cells, i.e., the spermatogonia, were always 224–58-negative. But the other germinal cells were 224–58-positive. This suggests that although 224–58 does not discriminate between SGC and seminolipid in serological ...
S-100 protein has been widely used as a Schwann cell marker both in vivo and in vitro (Spreca et al., 1989; Bolin et al., 1992; De Deyne et al., 1994; Gu et al., 1995). Many in vitro studies regarding Schwann cells have been developed using different cellular sources. These ...
A monoclonal antibody (mAb) designated 22458 (IgM-K) has been raised by fusion of Sp2/0-Ag14 mouse hybridoma cell line with spleen cells of a mouse immunized with human brain myelin. This mAb binds specifically to mouse, rat, and human Schwann cells membrane. Serological tests showed that ...
These progenitor cells initially develop into immature Schwann cells, which eventually differentiate into myelinating or nonmyelinating Schwann cells. These different cell types are distinguished by specific marker expression. Thus, Schwann cell progenitors express brain fatty acid binding protein (BFABP) ...
Schwannomas presented a strong staining in all tumor cells, whereas neurofibromas had a light speckled staining pattern, easily distinguishable from the one found in schwannomas. In conclusion, Glu-tubulin can be used as a marker of Schwann cells and can help in diagnosing peripheral nerve tumors...
Besides a morphology consistent with neural-competent, dedifferentiated Schwann cells (lower panel of Figure 1B; see also Figure S1 and Etxaniz et al., 2014), the Myf5+ cells expressed neural precursor cell marker NESTIN (Figure S1). To determine whether the Myf5+ cells from ventral skin ...
In contrast to acute peripheral nerve injury, the molecular response of Schwann cells in chronic neuropathies remains poorly understood. Onion bulb structures are a pathological hallmark of demyelinating neuropathies, but the nature of these formations is unknown. Here, we show that Schwann cells induce...
Schwann cells (SCs) are the most common glial cells in the peripheral nervous system and innervate peripheral nerves by interacting with axons and blood vessels [10]. SCs serve as a double-edged sword by engaging in axon creation and repair [11] but also perceiving harmful stimuli and relaying...
The olfactory mucosa contains OECs and myelinating Schwann cells from trigeminal afferents and other non-myelinating cells. Moreover, the close phenotypic resemblance of OECs and Schwann cells and the expression of marker molecules such as the neurotrophin receptor p75 (p75NTR) and glial protein ...
cells and included the neuronal differentiation marker NF200 (gating strategy Supplementary Fig.7a). We found that NF200 expression was significantly upregulated in theMYCNnon-amplified STA-NB-6 and SH-SY5Y NB cells after 16 days of direct contact to repair-related SCs (Fig.4b). Of note, ...