A person with schizophrenia replies: "My concentration often floats in and out so that I only hear part of a sentence. Maybe I will miss two or three words. This will make it very difficult for me to understand. Recently I went on a family outing. There were other families there and I...
Furthermore, some interventions, such as exercise training and bullying prevention programs are non-specific and likely to be beneficial for any youth, regardless the risk of developing schizophrenia. Nevertheless, the identification as a person at risk may have negative impact on a person's well-...
a brain area of key importance for higher cognitive functions, including working memory, attention, and executive function [223,224]. After promising preclinical investigations, the central acting and potent D1-receptor PAM mevidalen (LY-3154207) has been investigated in human studies and...
Recognizing this strain on families, many FPE programs emphasize the need for families to take care of their own health. "It's important to realize that the family has the right to education, support and counselling or whatever they need in their own right," says Baker. Families often don'...
was born in Chicago and reared in St. Louis by her. He began singing as a 3-year-old and was billed as “America’s Youngest Gospel Singer.”[2]She was the one who tried to develop his musical talents. She took him around singing in different programs, because it was evident from ...
JTM received partial salary compensation and funding from Merck MISP (Merck Investigator Sponsored Programs) but has no conflict of interest with this work. JTM, JMM, RES, REB and RB are Research Health Scientists at VA Boston Healthcare System, West Roxbury, MA. The contents of this work do...
or a reflection of other unknown altered developmental programs. Patient-derived neurons from iPSCs have not yielded robust observable differences in gene expression [37]. While issues of power have been suggested as the cause of the lack of observable differential expression between cases and control...
Specifically, the semantically correct and suitably chosen reply is transferred from Wernicke's region and the inferior parietal lobe, via the interlining axonal bundle, the arcuate fasciculus, to Broca's area which then programs the speech musculature and neocortical motor areas so that the reply ca...
Enrichment of synaptic, activity-dependent gene expression and protein homeostasis programs in deletion altered transcripts We next wondered how changes in gene expression caused by 22q11.2del might impact neurobiological processes. To this end, we first employed recently reported synaptic gene ontologies31...
The human research protection programs and institutional review boards of the participating institutions approved the design, experiments and consents (oral and written) used for the PING study. Subjects control (R>0.5) for all individuals from the PING database as of 6 April 2013. To control ...