To test whether SNPs nearer to the peak centers were more likely to be causal, we determined heritability enrichment of ATAC-seq peaks of varying widths (100 bp, 300 bp, 1 kb, 2 kb, 5 kb, and 10 kb). Schizophrenia SNP-heritability enrichment decreased as peak width increase...
Both brainstem and forebrain arousal centers innervate the thalamic network and are believed to provide dynamic modulation of the functional interaction between TRN-thalamocortical neurons, and ascending inputs to the cortex2,3. Specifically, ascending extra-thalamic inputs play an important role in the...
Opler et al. [41] also investigated gender differences in schizophrenia among homeless and housed study participants and found less substance abuse, fewer negative symptoms, and older age at first hospitalization in women. These differences may help women to adjust better than men to housing instabil...