The scFv-Fc format allows for rapid characterization of candidate scFvs isolated from phage display libraries before conversion into a full-length IgG. This format offers several advantages over the phage display-derived scFv, including bivalent binding, longer half-life, and Fc-mediated effector func...
This report describes the generation of a potent, fully human antibody fragment in scFv-Fc format efficiently targeting FGFR1. Antibody phage display was used to select high-affinity scFv antibody fragments against the extracellular domain of FGFR1(IIIc). Enzyme immunoassay (ELISA) and surface plasmon...
- 《Proceedings of the National Academy of Sciences》 被引量: 474发表: 1993年 Engineering antibody Fv fragments for cancer detection and therapy: Bisulfide-stabilized Fv fragments Disulfide-stabilized Fv fragments of antibodies (dsFv) are molecules in which the V-Vheterodimer is stabilized by an ...
Development of a highly potent bispecific antibody format targeting the novel tumor-specific antigen CLDN18.2 Due to multiple immune evasion mechanisms of cancer cells, novel therapy approaches are required to overcome the limitations of existing immunotherapies. B... Holland,Julia 被引量: 0发表: 201...
BCMA & CD3 Fab-scFv Fusion Proteins BCMA & CD3 IgG-IgG BCMA & CD3 IgG-scFv BCMA & CD3 Minibody BCMA & CD3 scFv-based Bispecific Fragments BCMA & CD3 Single chain IgGs BCMA & CD3 Single-chain Diabody BCMA & CD3 Tandem Diabody ...
融合基因anti-erbB2 scFv-Fc-CD28-CD3(ζ)的构建及真核表达隋文君, 苏世振, 胡望雄, 李红智*, 布立敬 (温州医学院浙江省重点医学遗传学实验室, 温州325035) 摘要 利用SMODEL预测该融合蛋白的三级结构。利用PCR的方法分别从重组pPIC9k、重组pBullet和pSecTag2B上扩增出3段基因片段,即片段anti-erbB2-scFv(简称...
CEA & HSG Bibody CEA & HSG Constant Domain-extended Bispecific Fragments CEA & HSG CrossMab CEA & HSG Diabody CEA & HSG Fab-Fv CEA & HSG Fab-IgG CEA & HSG Fab-scFv Fusion Proteins CEA & HSG IgG-IgG CEA & HSG IgG-scFv CEA & HSG Minibody ...
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Comparison of scFv and the Fc format of the anti-GBB5-H9.Michael R. KiernyThomas D. CunninghamRachida A. BouhenniDeepak P. EdwardBrian K. Kay
This result is the first example of the expression of an engineered anti‐CD20 antibody with a scFv‐Fc format at high levels in HR.ChiaraLaboratoryLonoceLaboratoryCarlaLaboratoryMarusicLaboratoryElenaLaboratoryMorrocchiLaboratoryAnnaLaboratoryMaria