A single-domain antibody library based on a stability-engineered human VH3 scaffold Article Open access 31 July 2024 DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously Article Open access 29 January 2021 Introduction Advances in recombinant antibody technology ...
In general, the antibody of the present invention comprises a framework with a VL and/or a VH domain, said framework being selected from at least part of a natural human antibody repertoire by an antigen independent method for high intracellular stability and solubility in a yeast cell. Said m...
1 . An isolated single chain variable fragment (scFv) comprising variable regions of the heavy (VH) and light chains (VL) of a monoclonal antibody, particularly a human or humanized monoclonal antibody, characterized in that the C-terminal end of said light chain is elongated by: i) an am...
To overcome these limitations, we developed a small-sized scFv antibody fragment conjugated with FITC for the real-time detection of colorectal cancer by in vivo molecular endoscopy imaging. A small-sized scFv fragment can target colon cancer secreted protein-2 (CCSP-2), highly expressed in ...
We decided to use this antibody/DOTA ratio for the study. The maximal specific activity was 400 MBq/mg. Stability in serum was also assessed by iTLC and was up to 93% 48 h after labeling (n = 1) (Fig. 3). Fig. 3 Radio-TLC analysis of [177Lu]Lu-1C1m-Fc (20 MBq of...