The Swiss pharma announced a deal with Precision BioSciences in 2022 in which it paid $75 million upfront to develop a curative in vitro gene therapy for SCD and beta-thalassemia. Precision is developing a custom ARCUS nuclease that Novartis will exclusively license. It could earn up to $1...
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8 Therefore, the Tanzania standard treatment guideline recommends using pneumococcal prophylaxis, especially in patients with SCD.9 The prophylaxis includes using oral phenoxy-methyl penicillin/penicillin V (PV) for children up to age five years and immunization against S....
Abnormal subchondral bone remodeling plays a pivotal role in the progression of osteoarthritis (OA). Here, we analyzed subchondral bone samples from OA patients and observed a significant upregulation of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) sp
开始日期2022-01-31 申办/合作机构- ACTRN12621000255886 /Completed临床1期 A Double-Blind, Randomised, Vehicle-Controlled Phase 1b Study to Evaluate the Safety and Pharmacokinetics of GDD3898 Topical Gel in Healthy Volunteers 开始日期2021-02-01 ...
A549 cells, an SCD1 inhibitor-resistant cancer cell line, underwent ER stress-dependent cancer cell death upon dual inhibition of SCD1 and FADS2. Thus, combination therapy with SCD1 inhibition and FADS2 inhibition is potentially a new cancer therapeutic strategy targeting fatty acid metabolism....
Western blotting showed that HBXIP was increased in these five HCC cell lines compared with that in the normal liver cell line LO2 (Fig. 1c). These results support the pro-tumor role of HBXIP in HCC development. We investigated whether sorafenib regulates the expression of the oncoprotein ...
2022, Journal of Hematology and Oncology Show abstract Targeting ROS in cancer: rationale and strategies 2024, Nature Reviews Drug Discovery Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions 2023, Signal Transduction and Targeted Therapy Protein tyrosine kinase inhibitor res...
Figure 5. AKR1C Family Is Highly Upregulated in STK11/KEAP1 Co-mutants (A) Heatmap of AKR1C expression in isogenic knockout clones from three cell lines. Expression shown is a Z score of the normalized TPM after removing the effect of cell line. Hierarchical clustering was performed using...
Methods The clinical data of 303 TB patients treated in the Fifth People's Hospital of Suzhou from October 2019 to January 2022 were retrospectively analyzed. The levels of sCD25 in plasma were detected by ELISA. Accord- ing to the cut-off threshold of ...