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SCCNV: a software tool for identifying copy number variation from single-cell whole-genome sequencing Version 1.0.2 Updated date: 2020.07.20 Author and License Author: Xiao Dong Email:biosinodx@gmail.com,xiao.dong@einsteinmed.org Licensed under the GNU Affero General Public License version 3 or...
近日,来自厦门大学化学化工学院的杨朝勇教授和嘉庚创新实验室张惠敏副研究员团队在单细胞全基因组测序领域取得重要突破,相关成果以“Digital microfluidics-based digital counting of single-cell copy number variation (dd-scCNV Seq)”为题发表于 Proc. Natl. Acad. Sci. U. S. A. (DOI: 10.1073/pnas.22219341...
We developed a single-cell DNA library preparation method without preamplification in nanolitre scale (scDPN) to address these issues. The method achieved a throughput of up to 1800 cells per run for copy number variation (CNV) detection. Also, our approach demonstrated a lower level of ...
Overview of SCYN We developed an algorithm, SCYN, that adopts a dynamic programming approach to find optimal single-cell CNV profiles. The framework for SCYN displayed in Fig.1A. First, the raw scDNA-seq reads of FASTQ format are pre-processed with standard procedures (Fig.1A). SCYN then...
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Mohs surgery, also called Mohs micrographic surgery, is a specialized technique for removing skin cancer. Named after its inventor, Dr. Frederic Mohs, Mohs surgery is the treatment of choice for many skin cancers. It offers the following advantages: Watch a 9 minute video about the basics of...
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