To study the development of new scars and progression of previous scarring, we analysed 711 children with primary VUR. New scar or progression of previous scarring was observed in 7.3% of the kidneys with reflux. Factors which promote the formation of new scars are high-grade VUR, recurrent ...
infection unless the kidneys were injured either by urinary obstruction (2), postinfectious scarring (3), massage =-=(4)-=-, or cauterization (5). ... AI Braude,AP Shapiro,J Siemienski - 《Journal of Clinical Investigation》 被引量: 326发表: 1955年 Matrix Metalloproteinase-9 and Tissue...
MRI of the kidneys employed a fat-saturated T1-W sequence and a post-gadolinium STIR sequence employing a short echo time. Results. Of the kidneys studied, 33 % ( n = 16) had evidence of a renal parenchymal defect suggestive of scarring on 99 m Tc-DMSA. The concordance in the ...
In addition, the following variables were determined: the age of the patient, diameter of the renal artery ostia, weight of the kidneys, heart weight, presence or absence of signs of sustained myocardial infarction, highest measured systolic blood pressure and the number of macroscopic renal scars...
Pecly, I. M. et al. Effects of low molecular weight heparin in obstructed kidneys: decrease of collagen, fibronectin and TGF-β, and increase of chondroitin/dermatan sulfate proteoglycans and macrophage infiltration.Nephrol. Dialysis Transplant.21, 1212–1222 (2006). ...
Both kidneys were excised 6 weeks later, for the evaluation of histopathologic changes, apoptotic damage, and concentrations of transforming growth factor-beta (TGF-beta). Only minimal changes were found in control samples. Pathologic scores of inflammation and fibrosis in group 1 were higher than ...
Morphological characterization of renal scars revealed no scarring in 35 refluxing kidneys (27.6%), while scars were noted in 4 of the 21 renal units in which voiding cystourethrography did not demonstrate reflux. The average number of scars plus or minus standard deviation per scarred kidney wa...
In the antibiotic plus melatonin group, melatonin and ceftriaxone were administered at the same dosages and duration as for the single-modality treatment groups. After 6 weeks, the kidneys were removed for malondialdehyde measurements and histopathologic examination (inflammatory response and cicatrization...
In the antibiotic plus melatonin group, melatonin and ceftriaxone were administered at the same dosages and duration as for the single-modality treatment groups. After 6 weeks, the kidneys were removed for malondialdehyde measurements and histopathologic examination (inflammatory response and cicatrization...
摘要: This article considers the pathogenesis of acute pyelonephritis; determinants of focal renal scarring; prevention of renal damage by early recognition of urinary tract infection in childhood; and renal growth patterns in kidneys damaged during early childhood. "...