14.Rheumatic heart disease is caused by damage to the heart valves and heart muscle from the inflammation and scarring caused by rheumatic fever. 风湿性心脏病是风湿热引起的炎症和伤疤使心脏瓣膜和心肌受损造成的。 15.The suit bore the..scars of a lifetime's responsibilities in its faded knee...
Using single cell RNA sequencing, the team found when fibrosis is triggered, a wide range of different macrophages—immune cellsthat clear foreign material in the body—are activated in a preclinical model of heart disease. While macrophages are mostly known for their role in removing cancer cells...
Eisenhardt SU, Schmidt Y, Thiele JR, Iblher N, Penna V, Torio-Padron N, et al. Negative pressure wound therapy reduces the ischaemia/reperfusion-associated inflammatory response in free muscle flaps. J Plast Reconstr Aesthet Surg. 2012;65(5):640–9. ArticleCASPubMed Daya M, Nair V. Tract...
Abnormal scarring imposes considerable challenges and burdens on the lives of patients and healthcare system. Macrophages at the wound site are found to be of great concern to overall wound healing. There have been many studies indicating an inextricably link between dysfunctional macrophages and fibro...
In the context of spinal cord injury (SCI), infiltrating macrophages assume prominence as the primary inflammatory cells within the lesion core, where the fibrotic scar is predominantly orchestrated by platelet-derived growth factor receptor beta (PDGFRβ+) fibroblasts. Galectin-3, a carbohydrate-bindi...
Rationale: Multiple biological mechanisms contribute to the efficacy of cardiac cell therapy. Most prominent among these are direct heart muscle and blood ... I Chimenti,RR Smith,TS Li,... - 《Circulation Research》 被引量: 858发表: 2010年 Macrophages mediate cardioprotective cellular postconditionin...
Proteomics and structural analysis revealed that excessive collagen deposition alone is not pathological, and can be compensatory, as revealed by overexpression of sarcospan and its associated ECM receptors in dystrophic muscle. Our in vivo data also supported that ECM remodeling is important for SMPC ...
TGF-β1 coordinately induces the expression of collagen type I and α-smooth muscle actin (α-SMA), of which the latter has been widely used as a myofibroblast marker (3). De novo expression of α-SMA together with other proteins such as non- muscle myosin or rho-kinase is impor- tant...
Following injury, inflammation-induced transforming growth factor β (TGFβ) activates the transition of corneal keratocytes into fibroblasts and myofibroblasts with the expression of α-smooth muscle actin (α-SMA) as key marker2,3,4,5. Myofibroblasts rapidly synthesize and secrete redundant ECM ...
Recruited CM-like cells organized in a partially striated and immature muscle fiber arrangement that presented connexin43 鈥攁 crucial mediator of cardiac electrical conductivity. Concomitantly, pcECM was rapidly vascularized, and induced a constructive remodeling process as indicated by increased M2/M1 ...