Like other organs, the liver responds to injury (e.g., from chronic alcohol ingestion) with scar formation (i.e., fibrosis). Specialized cells known as stellate cells play a major role in the development of liver fibrosis. Normally these cells serve as important storage depots for vitamin A...
In this stained micrograph, strands of activated hepatic stellate cells (blue) create characteristic “chicken wire” fibrosis in the liver and, in this case, a condition called steatohepatitis, which can be a precursor to subsequent cirrhosis, liver cancer and liver failure. Credit: Michael Bonert...
More than 3,000 middle-aged Framingham Heart Study participants (over a three-year period) underwent a test called a Fibroscan or vibration-controlled transient elastography that quantifies how much fat is in the liver and also measures the stiffness of the liver. Liver stiffness correlates with...
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Skin acts as the main protective barrier from the external environment. Compromise to this barrier, following trauma, burns, or surgical resection, can result in chronic wounds and scars that physically and emotionally devastate patients worldwide. Impro
Interleukin-13 (IL-13) is the dominant effector cytokine of fibrosis in pulmonary and liver disease. Excessive conjunctival fibrosis in the immunobullous d... VPJ Saw,I Offiah,RJ Dart,... - 《American Journal of Pathology》 被引量: 54发表: 2009年 Profibrotic Phenotype of Conjunctival Fibrobla...
Mesenchymal stem cells in the adult corneal stroma (named corneal stromal stem cells, CSSCs) inhibit corneal inflammation and scarring and restore corneal clarity in pre-clinical corneal injury models. This cell therapy could alleviate the heavy reliance on donor materials for corneal transplantation ...
Repair of wounds usually results in restoration of organ function, even if suboptimal. However, in a minority of situations, the healing process leads to significant scarring that hampers homeostasis and leaves the tissue compromised. This scar is characterized by an excess of matrix deposition that...
The most widespread member of this family, transglutaminase-2 (TG2), has a clear fibrogenic role contributing to the stabilisation and accumulation of the ECM consequent to lung, liver, heart and kidney fibrosis4–10. Extracellular TG2 has a number of substrates in the ECM including fibronectin...
Researchers have discovered that a key cell type involved in liver injury and cancer consists of two cellular families with different origins and functions.