The reactive astrocyte scar has long been regarded as uniformly detrimental to clinical outcome after CNS injury because of its inhibition of axon regeneration. Over the past twelve years, transgenic mouse models have enabled investigation of the mechanisms and functions of reactive astrocyte scar ...
Scar-forming astrocyteSpinal cord injuryβ(1)-integrinSpinal cord injury (SCI) causes reactive astrogliosis, the sequential phenotypic change of astrocytes in which nave astrocytes (NAs) transform into reactive astrocytes (RAs) and subsequently become scar-forming astrocytes (SAs), resulting in glial ...
Using electrophysiology, immunohistochemistry, fluorescent in situ hybridization, and Western blot analysis in different orthotopic xenograft and allograft models of human and mouse gliomas, we find that peritumoral astrocytes exhibit astrocyte scar formation characterized by proliferation, cellular hypertrophy,...
Methods: Microglia or astrocyte-specific MEGF10 or MERTK knockout mice were generated, and subjected to transient middle cerebral artery occlusion (tMCAO), or collagenase-induced intracerebral hemorrhage. Immunostaining, Transmission electron microscope and Western blot were used to evaluate synapse ...