In addition, SCAP also mediates the COPII-dependent ER-to-Golgi transport of SREBP2. When the intramembrane cholesterol level decreases, the SCAP-SREBP2 complex is transported to the Golgi, where SREBP2 is proteolytically activated to release its N-terminal transcriptionally matured form (5, 27)....
SREBP2和内质网上的另一个膜蛋白Scap(SREBP cleavage-activating protein)形成复合物。当细胞内胆固醇含量较高时,内质网上的Insig蛋白能够通过跨膜区与Scap蛋白的甾醇感受结构域(Sterol sensing domain,SSD)相互作用,将SREBP2-Scap复合物锚定在内质网上,从而降低细胞内胆固醇的吸收和合成。而当细胞内胆固醇含量降低时,Sca...
槲皮素通过SCAP/SREBP2/NLRP3通路减轻脂多糖诱导的急性肺损伤的影响 目的:探讨槲皮素对脂多糖(LPS)诱导产生的急性肺损伤(ALI)的影响及其可能的机制.方法:将40只雄性C57BL/6小鼠随机分为4组:LPS组,对照组,LPS+QUE组和QUE组,每组10只.对对... 敬和昆 - 重庆医科大学 被引量: 0发表: 2023年 TNF-α对肝...
目的:观察电针对高脂血症(HLP)大鼠固醇调节元件结合蛋白裂解活化蛋白(SCAP),固醇调节元件结合蛋白-2(SREBP-2)及其下游胆固醇代谢靶基因3羟基3甲基戊二酰辅酶A还原酶(HMGCR),前蛋白转化酶枯草溶菌素9(PCSK9),低密度脂蛋白受体(LDLR)表达...
SCAPSREBP2LDLr通路在LPS诱导人血管平滑肌细胞泡沫化中的作用,lps诱导巨噬细胞,lps诱导早产,平滑肌,平滑肌瘤,平滑肌肉瘤,胃平滑肌瘤,子宫平滑肌瘤,肾血管平滑肌脂肪瘤,子宫平滑肌肉瘤 文档格式: .pdf 文档大小: 941.15K 文档页数: 6页 顶/踩数: 0/0
The results showed that excess PI promoted SCAP-SREBP and NLRP3 complex translocation to the Golgi, potentially leading to NLRP3 inflammasome activation and lipogenic gene expression. Furthermore, PI amplified SARS-CoV-2 N protein-induced inflammation via the SCAP-SREBP pathway, which facilitates ...
产品活性:Fatostatin (125B11) 是 SREBP 活化的特异性抑制剂,可抑制 SREBP-1 和 SREBP-2 的活化。Fatostatin 与 SCAP (SREBP裂解激活蛋白) 结合,抑制 SREBPs 的 ER-Golgi 易位。Fatostatin 降低了细胞中成脂基因的转录。Fatostatin 具有抗肿瘤作用,能降低 ob/ob 小鼠的高血糖。
SREBP/SCAP-IN-2 (compound 13) acts as a selective inhibitor of SREBP/SCAP [1]. 化学信息 分子量 507.06 分子式 C27H37ClF2N4O CAS No. 2763493-94-1 储存&溶解度 存储 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. ...
Conversely, when cholesterol levels are excessive, INSIG binds the SCAP/SREBP2 complex and prevents SREBP transport to the Golgi.10 Despite a general knowledge of how this transport occurs and is regulated by cholesterol levels, many of its details remain to be discovered and characterized. S-...
PAQR3 promotes localization of Scap/SREBP in the Golgi There are two possibilities that may explain the enhancement of SREBP-2 processing by PAQR3: an increase in the enzyme activity of S1P/S2P or an increase in the localization of Scap/SREBP complex in the GA. To investigate the first poss...