Pharmaceutical granulesThe fluidized bed drying unit operation is extensively used in the pharmaceutical industry. However, there are still many unanswered questions with respect to scaling up fluidized bed drying operations. In this study, a scaling method for the fluidized bed drying process was ...
Accelerating Process Development. Dynochem’s right-first-time scale-up tools are used by chemists and chemical engineers at hundreds of pharmaceutical, agrochemical and CDMO sites in Asia, Europe and North America.
Scale-down modeling for successful scale-up and tech transfer One of the benefits of the use of smaller production facilities is a reduction in the scale-up factor for many biopharmaceutical processes. No longer are manufacturers required to scale-up from the lab to 20,000 L; more commonly pr...
Determining the scale-up factor. Many scale-up operations require more time than laboratory-scale experiments because the volume of materials is larger. R&D chemists should take into account the scale to which the process can be operated in the plant and the required time cycles for such process...
It is shown that the solution yields a single dimensionless parameter invariant in process scale-up or equipment transfer, which relates the densification factor with process parameters (roll force and gap), geometric parameters (roll diameter and width) and material properties. It is shown that, ...
This method of manufacturing is a minimal approach to the mechanistic understanding of a process. The development is mainly empirical with research often conducted one factor at a time (OFAT). Following manufacture, there would be little or no ‘design space’ defined, resulting in a strict manu...
If oxygen transfer is the limiting factor, then scale up by equal P/V will be essential. This method is adopted for many authors using larger-scale fermentors, such as these below 1000 L capacity (8). Current scale-up methods assume that, as in a small-scale fermentor, the...
For those SMEs whose turnover had remained stable (e.g. increased or decreased by 5%), turnover was nonetheless a more significant factor for measuring and defining growth. In contrast, for those whose turnover had increased by 20–30%, productivity, staff and research and development ...
The first factor to consider is the capacity of the scale. Capacity refers to the maximum weight that the commercial electronic scale can measure accurately. Ensure the commercial electronic scale can handle the weights typical to your industry. For example, a grocery store may need a scale with...
Apigenin NCs were produced at lab and pilot levels by applying a scale up factor of 150. 20 g product at lab scale was manufactured by HPH and the production was scaled up to 3 kg at pilot scale using CT (media milling followed by HPH), a smartCrystal technology. 4.3.1. Process Apige...