Scaffold Hopping(骨架跃迁)是药物设计中通过替换已知活性化合物的主骨架生成新分子的策略,旨在优化生物活性、成药性及突破专利
必应词典为您提供Scaffold-Hopping的释义,网络释义: 骨架迁越;骨架跃迁;跳跃式;
Scaffold hopping 骨架迁越 双语例句 1They were standing on top of a giant scaffold.他们站在一个巨大的脚手架顶上。《柯林斯英汉双解大词典》2All scaffold should be marked by blue marker before block final inspection, and the marker should be round and easily found.大厦最终检查之前，所有的脚手架...
碰巧的是,“骨架跃迁(scaffold hopping)”也有很多其他的名字。例如,它也曾经被称为先导跃迁(Lead hopping);基于竞争情报的先导化合物发现(Competitive intelligence-based lead discovery);基于类似物的药物发现(Analogue-based drug discovery);快速...
碰巧的是,“骨架跃迁(scaffold hopping)”也有很多其他的名字。例如,它也曾经被称为先导跃迁(Lead hopping);基于竞争情报的先导化合物发现(Competitive intelligence-based lead discovery);基于类似物的药物发现(Analogue-based drug discovery);快速跟随者(Fast follower);专利突破(Patent busting);仿造的药物方法(Me-to...
Scaffold hopping is a central task of modern medicinal chemistry for rational drug design, which aims to design molecules of novel scaffolds sharing similar target biological activities toward known hit molecules. Traditionally, scaffolding hopping depen
内容提示: TECHNOLOGIESDRUG DISCOVERYTODAYScaffold hoppingHans-Joachim Bo ¨hm, Alexander Flohr, Martin Stahl*Molecular Structure and Design, Pharmaceuticals Division, F. Hoffmann-La Roche AG, PRBD-CS, Building 092/3.56B, CH-4070 Basel, SwitzerlandThe aim of scaffold hopping is to discover ...
the practical application of 3D-SBDD generative models is hampered by their slow processing speeds. To address this bottleneck, we introduce TurboHopp, an accelerated pocket-conditioned 3D scaffold hopping model that merges the strategic effectiveness of traditional scaffold hopping with rapid generation ...
Scaffold-hopping from thienopyrimidine acids 1 and 2, supported by X-ray structure determination, identified 3-methylimidazolin-4-one amides 20-24 as potent inhibitors of Notum with activity across three orthogonal assay formats (biochemical, extra-cellular, occupancy). A preferred example 24 ...
(2004) Böhm et al. Drug Discovery Today: Technologies. The aim of scaffold hopping is to discover structurally novel compounds starting from known active compounds by modifying the central core structure of the molecule. Scaffold hopping is a central