Overview of the scDrugPrio workflow. Samples were derived from inflamed tissue in patients (red) and healthy tissues in controls (blue) or, for individual predictions, sampling included inflamed and uninflamed tissue taken from the same patient. Single-cell RNA-sequencing (scRNA-seq) data were p...
Symposium 2: “New insights into the effects of drugs of abuse and HIV on the brain from state-of- the-art single-cell studies” Chair: Dr. Howard Fox, Professor, Department of Neurological Sciences, Senior Associate Dean of Research and Development, College of Medicine, Speakers: 1. Dr....
We initially followed this approach, starting with the East side of amicarbalide, while maintaining the West-side amidine group and the benzamidino-ureido-phenyl scaffold (Fig. 1). All compounds were tested in vitro for their activity against asexual blood stages of the multi-drug-resistant P...
Although the pathophysiology of facioscapulohumeral dystrophy (FSHD) has been controversial over the last decades, progress in recent years has led to a model that incorporates these decades of findings and is gaining general acceptance in the FSHD resea
The MS proteomics data have been deposited to the ProteomeXchange Consortium (http://proteomecentral.proteomexchange.org) via the iProX partner repository (45) with the data set identifier PXD023557. Supplemental data This article contains supplemental data. Conflict of interest The authors declare no...
Colleagues in Cameroon, joined consortium members from Ghana, Nigeria, Liberia, LSTM and FHI360 for the 3-day meeting which offered opportunity for members of partner countries to discuss current status, and findings from the in-country multi-disciplinary research projects around neglected tropical ...
falciparum population, we checked the 3,500 samples from the MalariaGen consortium (https://www.malariagen.net/data/catalogue-genetic- variation-p-falciparum-v4.0). However, none of the mutations were found; all were de novo. The presence of both point mutations and gene amplification is ...