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However, due to the single-cell readout, it can be applied in a cell-type and state-specific manner and to primary cells such as T cells, B cells, hematopoietic stem cells, keratinocytes, and fibroblasts that can be transduced and expanded, but where the inability to clone cells normally ...
SCASL revealed the well-acknowledged differentiation trajectory from oligodendrocyte precursor cells to oligodendrocytes and astrocytes56(Fig.S8A). In addition, microglia and endothelial cells formed two small clusters very close to each other (Fig.S8A). Microglia are derived from blood monocytes/macroph...
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1b). GO terms associated with each gene were retrieved from Ensembl version 102 (ref. 103), accessed through the R package biomaRt (version 2.50.2)104. For a given LRI, we used the R package ontoProc (version 1.16.0)109 to build the ligand and receptor ontology subgraphs, whose nodes...
5A, B) but later in the more differentiated NK cell-specific path and T cell-specific path, these genes showed drastically different expression patterns, possibly leading to different cell fates. The above analysis used all protein coding genes as background for hypergeometric test. We have also...
B. Methyl 2-methoxy-4-benzyloxybenzoate: To an ice-cooled solution of methyl 2-hydroxy-4-benzyloxybenzoate from paragraph A (12.92 g, 50.1 mM) in DMF (200 mL) was added NaH in a 60% oil dispersion (3.00 g, 75.0 mM). The mixture was stirred for 5 min, at which time MeI (7.9 ...
Claims: The invention claimed is: 1.A method for manufacturing a shaped charge casing, comprising:mixing a metal powder or a metal powder mixture with a binder to form a pre-mix;pressing the pre-mix in a mold to form a casing green body;heating the casing green body to a first temperat...
Identifying cellular identities is a key use case in single-cell transcriptomics. While machine learning has been leveraged to automate cell annotation predictions for some time, there has been little progress in scaling neural networks to large data set
our results showed that COL11A1 mRNA expression and promoter activity was regulated by SC66 (Fig.4a, b), but not by MK-2206 (Supplementary Fig.5Aand5B). We also found out that the expression of PDK1, well known as the kinase responsible for the phosphorylation and activation of Akt22, ...