SB 590885 has been shown to decreases anchorage-independent growth of melanoma cell lines and also known to inhibit phosphorylation and proliferation. 别名 5-[2-[4-[2-(二甲基氨基)乙氧基]苯基]-5-(4-吡啶基)-1H-咪唑-4-基]-2,3-二氢-1-茚酮肟;SB-590885;SB-590885; SB 590885;5-[2-[...
The normal cells and tumor cells not expressing mutant B-Raf have no sensitivity towards SB590885 except the normal melanocytes and primary melanoma cells expressing wild-type B-Raf. Moreover, SB590885 is also found to decrease the transformed and tumorigenic properties of malignant cells ...
0.37 μM, 0.12 μM, and 0.15 μM, respectively. SB590885 decreases anchorage-independent growth of melanoma cell lines in a BRAF mutant-selective manner.[1]SB590885 displays high affinity for B-Raf with Kd of 0.3 nM.[2]Most of the melanoma cell lines that harbor the BRAF V600E mutati...