0.37 μM, 0.12 μM, and 0.15 μM, respectively. SB590885 decreases anchorage-independent growth of melanoma cell lines in a BRAF mutant-selective manner.[1]SB590885 displays high affinity for B-Raf with Kd of 0.3 nM.[2]Most of the melanoma cell lines that harbor the BRAF V600E mutati...