When bound to the C-2 atom of the glycerol molecule (as in pork lard), it is more hypercholesterolemic than in the C-1 position (such as in palm oil or cocoa butter). A reduction in total saturated fat intake should lead to a decreased consumption of the three aforementioned fatty ...
When unsaturated fatty acids go through chemical hydrogenation, the fatty acids take a trans configuration, which straightens the molecule so that it looks (and acts) more like a saturated fat. Food manufacturers like using trans fatty acids in their products because it extends the shelf life of...
The double bond in the unsaturated fatty acid is a cis structure, the molecule is curved, the structure is relatively loose, and the melting point is low. Both animal and vegetable oils contain saturated and unsaturated fatty acids, but usually animal oils contain more saturated fatty acids, an...
Failure of pancreatic and duodenal homeobox factor 1 (PDX1) to localise in the nucleus of islet beta cells under high-fat diet (HFD) conditions may be an early functional defect that contributes to beta cell failure in type 2 diabetes; however, the mechanism of PDX1 intracellular mislocalisati...
structure with specific properties (Lopez, 2005). In premature newborns with limited digestive capacities the native milk fat globule is much better lipolysed in the stomach than a formula (Armandet al., 1996b). In addition, the properties of the milk fat globule can be altered by some ...
Nutritionists explain why saturated fat might not be as damaging to our health as originally thought, and what that means for our every day diets.
making it easier to break one part of the double bond apart than it would be to break a single bond. hydrocarbon molecules which have no double bonds in them are called saturated. this simply means that there are as many hydrogen atoms as possible in the molecule, and no more can be ad...
The LIPID MAPS structure database (LMSD; www.lipidmaps.org) gives the structures of biologically relevant lipids [7]. TAGs are main components of oils and fats of plant and animal origin. The number of TAGs found in a particular oil or fat is determined by the specificity of enzymes ...
To functionally inhibited MD2 in this system, we used a small-molecule inhibitor of MD2 (L6H9; Supplementary Fig. 3a) and Md2 short interfering RNA (siRNA) transfection. We have previously characterized the anti-inflammatory activity of L6H9 in LPS-stimulated macrophages32 and report that L6H9 ...
(MCP-1) and intracellular adhesion molecule 1 (ICAM-1) in the cardiac tissues as additional indicators of local inflammatory response activation. IL-6 is known to increase both MCP-1 and ICAM-1 expression31and facilitate monocyte recruitment. In the wild-type mice, PA increased expression of ...