Effect of sarsasapogenin and its derivatives on the stimulus coupled responses of human neutrophils. Clin Chim Acta 2001; 314: 107–12. Article CAS Google Scholar Hu YE, Xia ZQ, Sun QX, Orsi A, Rees D . A new approach to the pharmacological regulation of memory: sarsasapogenin improves ...
Sarsasapogenin is an A/B- cis spirostane steroidal sapogenin having the structure:[0005] Derivatives are known, of which there may particularly be mentioned esters formed with the free OH group atthe 3-position carbon atom in the A (left hand end) ring, for example carboxylic acid esters su...
Polymorphs of sarsasapogeninThe invention provides sarsasapogenin in novel amorphous, crystalline, solvated and hydrated forms, and the use thereof in manufacturing pharmaceutical or edible grade sarsasapogenin and its derivatives.彼得·大卫·蒂芬
Sarsasapogenin, extracted from Anemarrhena asphodeloides Bunge., has been reported to protect neurons from H2O2-induced damage. In the current study, four series of 26-amino acid methyl ester substituted sarsasapogenin derivatives (5a-5e, 5f-5j, 6a-6e and 7a-7e) were synthesized and tested for ...
particularly high inhibitory activity on the growth of various brain tumor cells, having potential wide application and tremendous value in treating various cancers, making up for the deficiency of modified derivatives of sarsasapogenin in the prior art and having important scientific and commercial applic...
Polymorphs of sarsasapogeninThe invention provides sarsasapogenin in novel amorphous, crystalline, solvated and hydrated forms, and the use thereof in manufacturing pharmaceutical or edible grade sarsasapogenin and its derivativesdoi:EP2479183 A2Tiffin Peter DavidEP...
WenbaoZhangYingyingYaoGuodongWeiShangXinyueYanXiaoboShaojieSongShaojiangWang, W., Zhang, Y., Yao, G., et al. (2018), Synthesis of new sarsasapogenin derivatives with antiproliferative and apoptotic effects in MCF-7 cells, Steroids, 131: 23-31....
Derivatives based on the sarsasapogenin structure of Zymo, drug compositions and uses thereofIn the derivative based on the sarsa sapogenin structure of Zymo, the structural formula of the derivative is represented by the following general formula (I), general formula I The present invention also ...
The present invention belongs to the field of medical technology, involving altogether high purity sarsasapogenine its preparation method and pharmaceutical new uses derivatives. 将知母药材用含水乙醇或和水提取,采用大孔吸附树脂吸附洗脱,酸水解,重结晶,制备高纯度菝葜皂苷元纯度达98%. The medicine altogether...
Polymorphic form of sarsasapogeninThe novel amorphous form, crystal forms, solvated forms, and sarsasapogenin hydrated form, as well, the present invention provides their use in the preparation of its derivatives and sarsasapogenin food grade or pharmaceutical.ピーター デイビッド ティフィン...