SARS-CoV-2属于冠状病毒β家族,包膜上有刺突,刺突糖蛋白(Spike glycoprotein,S protein)是SARS-CoV-2的主要包膜蛋白,血管紧张素转化酶2(Angiotensin converting enzyme 2,ACE 2)是SARS-CoV-2的主要受体,广泛分布于人体的各种组织中。ACE2与SARS-CoV-2结合后可以引起S蛋白构象发生改变,并在跨膜丝氨酸蛋白酶2(Trans...
SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as 2019-nCoV (2019 Novel Coronavirus) is a virus that causes illnesses ranging from the common cold to severe diseases. SARS-CoV-2 Spike Protein is composed of S1 domain and S2 domain. S1 contains a receptor-binding dom...
Exposure to the spike protein or receptor-binding domain (S-RBD) of SARS-CoV-2 significantly influences endothelial cells and induces pulmonary vascular endotheliopathy. In this study, angiotensin-converting enzyme 2 humanized inbred (hACE2 Tg) mice and cultured pulmonary vascular endothelial cells ...
Yeast-Expressed Recombinant Protein of the Receptor-BindingDomain in SARS-Cov Spike Protein With Deglycosylated Forms as a SARS VaccineCandidate. Hum Vaccines Immunother (2014) 10:648–58. doi: 10.4161/hv.27464 CrossRef F...
Most of the ongoing projects aimed at the development of specific therapies and vaccines against COVID-19 use the SARS-CoV-2 spike (S) protein as the main target. The binding of the spike protein with the ACE2 receptor (ACE2) of the host cell constitutes
as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be tra...
在一项新的研究中,来自中国军事医学科学院、西湖大学和清华大学的研究人员从10名康复期COVID-19患者中分离并描述了mAb。相关研究结果于2020年6月22日在线发表在Science期刊上,论文标题为“A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2”。
SARS-CoV-2 has a zoonotic origin and was transmitted to humans via an undetermined intermediate host, leading to infections in humans and other mammals. To enter host cells, the viral spike protein (S-protein) binds to its receptor, ACE2, and is then pro
货号:Spike RBD用途范围:药物开发等 规格:100ug是否进口:否 SARS-CoV-2 (COVID-19) S protein RBD, His Tag (MALS verified) 分子别名(Synonym) Spike,S protein RBD,Spike glycoprotein Receptor-binding domain,S glycoprotein RBD,Spike protein RBD ...
使用HIV-1(人类免疫缺陷I 型病毒)为基础载体转染293T细胞后,包装成SARS-CoV-2 (B.1.621) Spike 假病毒,表面表达SARS-CoV-2 (B.1.621) Spike Pseudovirus蛋白,并携带有荧光素酶报告基因,可用于侵染过表达ACE2的细胞,荧光素酶在细胞内表达。此假病毒无自主复制能力,具有安全性高、可操作性强等特点。