【科技前沿】张宏团队揭示SARS-CoV-2抑制自噬溶酶体形成的机制 细胞自噬（autophagy）是一种在真核生物中高度保守的由溶酶体介导的胞内降解途径。自噬通过形成双层膜的自噬体包裹胞质中的待降解组分，随即运输至溶酶体进行降解。细胞自噬对于细胞应对各种应激条件以及维持稳态平衡至关重要，并且能够参与抵抗外来入侵的病原...
Here, we provide intriguing evidence for the existence of a unique relationship between SARS-CoV-2 and the molecular hallmarks of aging, specifically impacting protein degradation through autophagy and mitochondrial quality control, pointing toward a profound shift in the risk profile for the onset of...
SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals 原文链接:https://mp.weixin.qq.com/s/SbHarofFZuAgIiP7HWCQ3Q 下载iSeq 100产品手册,了解Illumina最经济适用的NGS解决方案 领取赛业生物小动物疾病模型详细技术资料>> Illumina iSeq 100测序系统和AmpliSeq for Il...
来自中山大学的崔隽教授和金寿恒副教授研究团队发表了题为“Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy”的研究论文,该研究发现SUMO化修饰和泛素化介导的ACE2选择...
Here, given the interaction of viruses with macroautophagy (hereafter referred to as autophagy), a CQ-sensitive anti-viral safeguard pathway, we would like to discuss the pros, but also the cons concerning the current therapeutic options targeting this process....
P. et al. Metformin enhances autophagy and normalizes mitochondrial function to alleviate aging-associated inflammation. Cell Metab. 32, 44–55 (2020). Article CAS PubMed PubMed Central Google Scholar Polack, F. P. et al. Safety and efficacy of the BNT162b2 mRNA COVID-19 vaccine. N. ...
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the causative agent of the pandemic disease COVID-19, which is so far without efficacious treatment. The discovery of therapy reagents for treating COVID-19 are urgently needed, and the stru
autophagy and inflammatory pathways, but they also affect the plasma membrane, MAP kinases, calcium signalling, as well as DNA [185]. They can also modulate mitochondrial function [186,187,188] and have been shown to have anti-oxidant activity [189]. Paradoxically, they can also induce oxidati...
Chloroquine (CQ), a drug well-known for its effectiveness in treating malaria and autoimmune disease and hydroxychloroquine, has shown encouraging inhibitory results against viruses. Such drugs obstruct the lysosomal activity and autophagy, changing signaling pathways membrane stability, and transcription mec...
学系山东省感染与免疫重点实验室高成江教授和中国广东省深圳市第三人民医院国家传染病临床研究中心肝病研究所张政研究员作为通讯作者,合作在《The Journal of Immunology》杂志上发表了一篇论文,题目为SARS-CoV-2 NSP13 Inhibits Type I IFN Production by Degradation of TBK1 via p62-Dependent Selective Autophagy。