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#: WT: WAS Lot 1215020-1235, Delta:NR-56116, and Omicron:NR-56486). The intranasal inoculation (IN) was performed on Ketamine/Xylazine anesthetized hamsters. The animals were challenged with a total volume of 100 μL per animal (50 μL/nare). The infectious titers of the WT stock are ...
We have employed an efficient structure-based virtual screening protocol to search for novel inhibitors of SARS-CoV-2. The binding potential of several compounds was tested on multiple structures of Mpro, and consensus strategy was applied to select the most promising binders. Based on the ...