The impact of SARS-CoV-2 infection on the WAT of aged individuals has not previously been characterized. To address this knowledge gap, we compared the effects of SARS-CoV-2 infection on SCAT and VAT depots in young adult vs. aged golden hamsters. We found that SARS-CoV-2 infection impair...
3a, E, M, 6, 7a, 7b, 8, and N) which form the structural and accessory proteins. These sgRNAs are produced by the canonical Transcription Regulatory Sequence (TRS) mediated mechanism for discontinuous transcription [57,70].
Furthermore, the finding of IgG and IgM antibodies against SARS-COV-2 in seronegative neonates of COVID-19 infected mothers [93], [99], [100], [101] especially of IgM antibodies that cannot cross the placenta, suggest a fetal immune response against the virus in neonates born to infected...
133,134]. Low miR-155 levels on the other hand, as in the old and/or in comorbidities, could explain a RAAS hyperactive state with cytokine storm [76,100,101,135]. It is to date unclear how miR-155 finetunes this delicate
Disadvantages of the LAV platform include the requirement for extensive quality control and characterization to ensure that the vaccines do not revert back to a less attenuated form and they require cold storage (2–8 °C) [169]. Further, these vaccines cannot be used in the immunocompromised ...
Antibody Response Post SARS-CoV-2 Vaccination in Kidney Transplant Recipientsdoi:10.1681/ASN.20213210S1101cMaria ButiuNicolae LecaRamasamy BakthavatsalamAmerican Society of NephrologyJournal of the American Society of Nephrology
The newly emerging coronavirus SARS-CoV-2 causes severe lung disease and substantial mortality. How the virus evades host defense for efficient replication is not fully understood. In this report, we found that the SARS-CoV-2 nucleocapsid protein (NP) im
particular, in VAT is inflammatory if it becomes overloaded. As the virus seems to induce oxidative stress [164] and aerobic glycolysis to enhance its own replication, it could be argued that in a person with poor mitochondrial and anti-oxidant reserve, infection will tend to tip towards ...
Tukhvatullin, D.V. Shcheblyakov, A.S. Dzharullaeva, D.M. Grousova, A.S. Erokhova, A.V. Kovyrshina, A.G. Botikov Safety and immunogenicity of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine in two formulations: two open, non-randomised phase 1/2 ...
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