332k Accesses 2464 Citations 1822 Altmetric Metrics details Abstract Although most mutations in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome are expected to be either deleterious and swiftly purged or relatively neutral, a small proportion will affect functional properties ...
11k Accesses 19 Citations 63 Altmetric Metrics details Abstract Emergence of new viral agents is driven by evolution of interactions between viral proteins and host targets. For instance, increased infectivity of SARS-CoV-2 compared to SARS-CoV-1 arose in part through rapid evolution along the ...
Another way is that you can go to the SARS website and use their Online Query function or simply call the SARS contact Centre at 0800007277. SARS will not disclose your tax reference number to a third party, unless the individual is your tax professional or holds your Power of Attorney (...
SARS-CoV-2 is used as a reference sequence query. First, we performed the similarity plot analysis with a total of 284 complete genome sequences of SARS-CoV-2 related bat/pangolin viruses and SARS-CoV-related viruses. Next, representative sequences are selected presented here. Details are ...
If gloves come in contact with the specimen, immediately change them to prevent contamination of other specimens. 1. Nasopharyngeal or anterior nasal swab specimens should be collected and expressed directly into the BD Universal Viral Transport System or the Copan Universal Transport Media System ...
Although most of the contact sites of this compound are intolerant to mutation, several demonstrate significant plasticity in our data. These include Glu166 at the S1 subsite, which through its side chain forms a hydrogen bond with the lactam ring of nirmatrelvir at the P1 position. From our...
SARS-CoV-2 is believed to have originated in a seafood market in Wuhan, Hubei Province, China [29], although limited contact-tracing at the beginning of the pandemic does not allow for definitive characterization of the exact events that led to the first human-to-human transmis- sion, ...
SARS-CoV-2 is believed to have originated in a seafood market in Wuhan, Hubei Province, China [29], although limited contact-tracing at the beginning of the pandemic does not allow for definitive characterization of the exact events that led to the first human-to-human transmission, including...
Because of the standardized and identical procedure of notification dur- ing the whole observation period of this study through- out Germany and widely established cost-free test systems (including public test stations) that immediately contact local health authorities in case of a positive PCR- test...
2869 Accesses 84 Altmetric Metrics details Abstract Although antibody escape is observed in emerging severe acute respiratory syndrome coronavirus 2 variants, T cell escape, especially after the global circulation of BA.2.86/JN.1, is unexplored. Here we demonstrate that T cell evasion exists in ...