Figure 2. Mean Number of Contacts per Household, Secondary Attack Rate (SAR) of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), and Proportion of Households Reporting Any Secondary Transmission From Index Cases View LargeDownload The expected proportion of households with any secondary ...
50Citations 60Altmetric Metrics Abstract COVID-19, the disease caused by SARS-CoV-2, has claimed approximately 5 million lives and 257 million cases reported globally. This virus and disease have significantly affected people worldwide, whether directly and/or indirectly, with a virulent pathogen ...
The main protease of SARS-CoV-2 (Mpro) is an important target for developing COVID-19 therapeutics. Recent work has highlighted Mpro’s susceptibility to undergo redox-associated conformational changes in response to cellular and immune-system-induced ox
Figure S1A shows the number of mutant sequences per residue at positions undergoing mutations in independent lineages. This can be interpreted in two ways: one is that the later mutations are epistatic to one another and thus are more difficult to reach, or that they do not contribute to ...
One unique feature of the SARS-CoV-2 pandemic is its high asymptomatic carrier rate (up to 46%), which has been an underlying factor for this coronavirus’s unprecedented spread across the globe [8,9]. A meta-analysis suggests that SARS-CoV-2 infection has an incubation period of 5–7 ...
Depending on the viral load and availability of permissive cells, the number of infecting viruses per cell (known as multiplicity of infection, MOI), denoted in our work as [Vfree](0)[Vfree](0), can vary substantially (see the discussion in [19]). We examine the effect of various MOI...
In group 1 (SARS-CoV-2), a morbidity rate of 40% was observed (4 out of 10 mice presented clinical signs and were sacrificed), while in mice belonging to group 2 (BCG-SARS-CoV-2), the morbidity rate after SARS-CoV-2 infection was 60% (6 out of 10 mice) (OR = 2.25 95%...
The false-negative rate in the early phases of the pandemic has been reported to range from 2% to 29%. The specificity of molecular RNA assays is excellent. ANTIGEN Tests detect viral proteins, e.g., SARS-CoV-2 spike protein. Data from 2022-2023 found lower sensitivity of anti...
However, between day 28 and 90 post-booster, we observed a rapid decline in B.1.1.529 nAbs, resulting in loss of seropositivity in seven out of 40 (17%) participants, and anti-S IgG titer waning at a rate of 1.47% per day. These findings align with a study among HCWs in Israel ...
As a result, lipid rafts act as plasma membrane "chambers" that facilitate protein interactions on the plasma membrane, promote the rate of molecule collisions, and consequently improve the efficacy of membrane reactions. Fig. 3 Lipid rafts play a role in viral infection by providing appropriate ...