Since the onset of the pandemic, many SARS-CoV-2 variants have emerged, exhibiting substantial evolution in the virus’ spike protein1, the main target of neutralizing antibodies2. A plausible hypothesis proposes that the virus evolves to evade antibody-mediated neutralization (vaccine- or infection...
The main protease of SARS-CoV-2 is an attractive drug target since it has an essential role in the processing of viral polyproteins and host–cell signaling proteins and it has no human homolog. Previous works have demonstrated the feasibility of this approach.17., 18., 19., 20., 21.,...
Main The post-acute sequelae of SARS-CoV-2 infection—also referred to as Long COVID—have been characterized1. Increasingly, vaccinated individuals are being diagnosed with COVID-19 as a result of breakthrough SARS-CoV-2 infection (BTI)2,3. Whether people with BTI experience post-acute seque...
Most of the ongoing projects aimed at the development of specific therapies and vaccines against COVID-19 use the SARS-CoV-2 spike (S) protein as the main target. The binding of the spike protein with the ACE2 receptor (ACE2) of the host cell constitutes the first and key step for vir...
The genome of SARS CoV is that of a typical coronavirus. The viral genomic RNA has at least 14open reading frames(ORFs) (Figure 1). The genome codes for 16 nonstructural proteins (nsp1–16), 5structural proteins, and 7accessory proteins. The genomic RNA encoding the replicase gene functions...
structural proteins of SARS-CoV-2, can be targeted by neutralizing antibodies. The two main structural proteins for targeting are nucleoprotein and spike protein. The nucleoprotein is surrounded by a viral cellular membrane, making it less preferable in serosurvey than spike protein. The robustness ...
Main Outcomes and Measures Confirmed SARS-CoV-2 infection among participants within the BAMSE cohort. Distributed-lag models combined with conditional logistic regression models were used to estimate the association. Results A total of 425 cases were identified, of whom 229 (53.9%) were women, and...
The COVID-19 diagnosis codes were not used because previous internal reviews had shown them to be less accurate than the PCR test and EHR flags. For example, diagnostic codes could refer to the incidental date of infection, but they also may refer to a follow-up appointment.18 Cases were ...
Table 1 presents descriptive statistics for the variables used in the main analysis, both for the whole sample and for each outcome group. Supplementary Fig. 2 shows that the majority of the included individuals had their pre-infection healthcare utilization measured approximately two years ago, and...
Source data Full size image We found that spike(D796H) alone and the spike(D796H, ΔH69/ΔV70) double mutant were less sensitive to neutralization by convalescent plasma samples (Fig. 4c–e and Extended Data Fig. 7). By contrast, the spike(ΔH69/ΔV70) single mutant did not reduce...