Dominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complex. EMBO J. 16, 1153–1163 (1997). CAS PubMed PubMed Central Google Scholar Miorin, L. et al. SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize...
with the intriguing finding that overexpression of p6 inhibits nuclear import of STAT1 in cells treated with IFN-β (Kopecky-Bromberg et al., 2007). Further studies by the same group revealed that p6 can physically interact with karyopherin alpha 2 (KPNA2) and tether it to the rough ER (...
Karyopherins and nuclear import. Curr. Opin. Struct. Biol. 11, 703–715 (2001). Article CAS PubMed Google Scholar Lott, K. & Cingolani, G. The importin β binding domain as a master regulator of nucleocytoplasmic transport. Biochim. Biophys. Acta 1813, 1578–1592 (2011). Article CAS ...
Using tree_as_of for custom clade assignments is an advanced feature and requires Docker. >>> from cladetime import CladeTime # Create a CladeTime object that references the most recent available sequence # data and metadata from Nextstrain >>> ct = CladeTime() Accessing sequence data Each ...
After a while a message will inform that the installation (import) was completed. Step 6: Set the password for VIPER. It will be exhibited the total amount of RAM and Threads (processors) of the computer that VIPER is being installed. Since VIPER runs in WSL, the user will need to ...
SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling Proc. Natl. Acad. Sci. U.S.A., 117 (2020), pp. 28344-28354, 10.1073/pnas.2016650117 View in ScopusGoogle Scholar [16] K. Kato, D.K. Ikliptikawati, A. Kobayashi, H. Kondo, K. Lim,...
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Predictions by the import model need to be scaled by a factor between 1.2 and 12 (see legends in individual plots) to match the observed frequencies (see main text for discussion). Fluctuations on short time scales in the observed frequency of 20E (EU1) are probably due to sampling and ...
and export.62In a study involving SARS-CoV infected cells, a competing endogenous RNAs (ceRNAs) network was identified.63Among these, the involvement of one mRNA antiviral innate immune response receptor RIG-1 (Ddx58) in the processes of mRNA splicing and miRNA biogenesis results in reprogramming...