Tests were carried out as a conventional case-control setup, and for each SNP a contingency table was constructed as (deceased patients with SNP/ deceased patients without SNP)/(non-deceased patients with SNP/ non-deceased patients without SNP). P-values were calculated using Fisher’s exact tw...
Interestingly, nitrile 15 inhibited SARS-CoV-2 progression in infected cells ∼2-fold more efficient than alkyne 13 (EC50 ∼ 11.8 μM for 15 and ∼25.7 μM for 13; Table 1, entries iv and ii), despite its ∼6-fold reduced potency in inhibiting isolated Mpro (Table 1). Note ...
In late 2022, SARS-CoV-2 Omicron subvariants have become highly diversified, and XBB is spreading rapidly around the world. Our phylogenetic analyses suggested that XBB emerged through the recombination of two cocirculating BA.2 lineages, BJ.1 and BM.1.1.1 (a progeny of BA.2.75), during th...
Table 1. Summary of studies that reported the incidence of C. pneumoniae co- and secondary infection in COVID-19 patients. ReferenceCity, countryType of studyType of pts. AgeaNo. of pts. with COVID-19 studiesNo. of pts. COVID-19 confirmedOverall rate of co- infectionNo. of patients wi...
As of August 10, 2022, Singapore had recorded a total of 1,773,386 cases and 1543 fatalities [61]. The case fatality rate is therefore around 0.09%, much lower than the rate with SARS cases (See Table 1). In terms of the government decision-making of health emergencies, the Singapore...
The article provides information on the patent activity of inventors in relation to applications for inventions related to coronaviruses, in particular, to
(3600) RT-PCR; Ct, 45 ND NA 0/18 Santarpia et al, 2020 IW Mild IRs Negative pressure Bedside table or desk 15 min (750) RT-PCR; Ct, 45; viral culture NA 0/10 0/18 Guo et al, 2020 GW Mild Single bay room 8 Air supplies and 12 air discharges/h Near patients, near air ...
the emergence of multiple SARS-CoV-2 variants around the world and potential insufficient coverage of vaccinations in the overall population call for the development of effective therapeutic treatment options. As listed in Table1, pharmacologic interventions on adenosinergic signaling and HIF signaling coul...
1). Technical validation performed with a set of 6 samples (4 vaccinated, 1 infected, 1 pre-pandemic) confirmed that RBDCoV-ACE2 is highly reproducible, as seen by the low intra- and inter-assay variation (all CVs under 5% and 7% respectively, Figure S1a and b, Table S3). ACE2 ...
We determined cryo-EM structures for the spike complexes with antibodies 1-68, 1-87, and 2-51 at overall resolutions of 3.8, 3.63, and 3.71 Å, respectively (Figures 1B and S3A; Table S1). We also produced a locally refined cryo-EM map around the antibody:spike interface for 1-87...