A vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is needed to control the coronavirus disease 2019 (COVID-19) global pandemic. Structural studies have led to the development of mutations that stabilizeBetacoronavirusspike proteins in the prefusion state, improving their expre...
Vaccine development research is necessary for controlling transmission, improving community immunity, and preventingfurther SARS-CoV-2 resurgence. The various approaches to future vaccine development can be broadly classified into either protein subunit, plasmid DNA, mRNA, or viral vaccines....
R-CNP@M组的肺部和鼻腔中的SARS-CoV-2病毒RNA和感染性病毒数量显著低于PBS组(图 3i、j),进一步证明其免疫保护效果。通过免疫组织化学和苏木精-伊红染色,观察到PBS组肺部中有大量的SARS-CoV-2核衣壳蛋白、明显的肺泡间隔增厚和显著的炎症细...
First encounter with SARS-CoV-2: immune portraits of COVID susceptibility Controlled infection with SARS-CoV-2 of people who hadn’t previously been exposed to the virus reveals how molecular and cellular signatures of the immune response portend effective defence against COVID-19. ...
在一项新的研究中,美国第一个进入人体试验的SARS-CoV-2实验性mRNA疫苗在一种经过精心改造的刺突蛋白的帮助下,已被证实能引起中和抗体和有益的T细胞反应。相关研究结果于2020年8月5日在线发表在Nature期刊上,论文标题为“SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness”。这种称为mRNA-...
在一项新的研究中,美国第一个进入人体试验的SARS-CoV-2实验性mRNA疫苗在一种经过精心改造的刺突蛋白的帮助下,已被证实能引起中和抗体和有益的T细胞反应。相关研究结果于2020年8月5日在线发表在Nature期刊上,论文标题为“SARS-CoV-2 mRNA ...
This is the first study to report immunogenicity of a recombinant spike vaccine in humans. Corbett, K. S. et al. SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness. Nature https://doi.org/10.1038/s41586-020-2622-0 (2020). Hsieh, C. L. et al. Structure-based ...
Challenges in universal vaccine design against SARS-CoV-2 The development of a new vaccine is a long-distance race between the virus and humans. Although tremendous progress has been made in reducing the viral transmission and fatality rate via vaccine administration, the emerging variants are challe...
在一项新的研究中,美国第一个进入人体试验的SARS-CoV-2实验性mRNA疫苗在一种经过精心改造的刺突蛋白的帮助下,已被证实能引起中和抗体和有益的T细胞反应。相关研究结果于2020年8月5日在线发表在Nature期刊上,论文标题为“SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness”。这种称为mRNA-...
关于定义为SARS-CoV-2疫苗或SARS-CoV疫苗或冠状病毒疫苗并用于治疗目的的干预的任何研究,无论是作为唯一疫苗还是作为抗病毒SOC或护理标准的佐剂,其中包括不同的预防性候选疫苗、具有多种佐剂的候选疫苗、几种RNA疫苗、DNA疫苗,以及经过技术改造的活疫苗。数量或疫苗接种计划没有限制。控制集是否存在;如果存在,他们可能...