Therefore, new treatment strategies are needed to control or prevent lung metastasis and improve the long-term survival rate.doi:10.1385/1-59259-323-2:495Shu-Fang JiaRong-Rong ZhouEugenie S. KleinermanHumana PressJia S F; Zhou R R; Kleinerman E S.Nude mouse lung metastases models of ...
subcutis, lymph nodes, liver, spleen and/or bone marrow. In the one reported case, the subcutaneous tumours were assumed to be primary, with evidence of metastasis to the skeletal muscles, mediastinal lymph nodes, pericardium
The most threatening tumours are those that invade and destroy healthytissuesin the body’s majororgansystems by gaining access to the circulatory orlymphatic systems. The process of spread, accompanied by the seeding of tumour cells in distant areas, is known asmetastasis. Tumours that grow and ...
Sarcoma is a malignant tumor that originates from mesenchymal tissue. The common treatment for sarcoma is surgery supplemented with radiotherapy and chemotherapy. However, patients have a 5-year survival rate of only approximately 60%, and sarcoma cells are highly resistant to chemotherapy. Ferroptosis...
The complete removal of all brain metastases and a Karnofsky performance score > 70 are associated with a favorable prognosis, whereas the presence of concurrent lung metastases is not a contraindication to surgery. 展开 关键词:Brain metastasis Brain neoplasm Sarcoma ...
(Brown 2008). Uterine LMS generally infiltrate into the adjacentmyometriumand may reach the vascular bed, implying an increased potential for metastasis (Ahluwaliaet al.2006). LMS tumors can disseminate locally and regionally to the gastrointestinal and urinary tracts, whereas hematogenous spread ...
Although conventional modalities predominate in sarcoma treatment, new approaches to target aberrant signalling with specific therapies, overcome acquired resistance and target unconventional pathways are rapidly evolving.Abstract Increasingly, human mesenchymal malignancies are being classified by the abnormalities ...
The patients with lung metastasis that have a longer VDT should therefore be considered for aggressive treatment even if the lesions are multiple and/or bilateral.doi:10.1007/s10585-011-9413-9Tomoki NakamuraAkihiko MatsumineTakao MatsubaraKunihiro Asanuma...
With regard to safety, between both cohorts, 8 patients experienced grade 3 adverse effects (AEs): 1 patient in cohort A, 3 in cohort B, 2 in cohort C and 2 in cohort D. Moreover, 1 patient developed metastasis while receiving neoadjuvant treatment. Unique grade 3 AEs included renal fail...
lines, however, MSO treatment was able to completely block the effect of glutamate and ammonia addition (Fig.3b). Taken together, these findings suggest that GS activity is necessary for glutamine-deprived proliferation of pediatric sarcomas, and that the effects of MSO are specific to GS ...