While vaccines that provide pan-SARS-CoV-2 immunity would be of immediate interest in the context of the continuing pandemic, there is particular interest in the development of pan-sarbecovirus vaccines that elicit a protective antibody response towards non-SARS-CoV-2 sarbecoviruses. Tan et al....
To define CD8+ T cell epitopes within highly networked regions of SARS-CoV-2, we utilized a prioritization pipeline that integrates computational epitope prediction with experimental HLA class I stabilization (Figure 3A). Epitope network scores were calculated (see STAR Methods, method details) for ...