综上，亮氨酸受体SAR1B和Sestrin协作共同调控mTORC1信号（图2e）。图2. 亮氨酸受体SAR1B和Sestrin协同调控mTORC1。 (a) SAR1B和Sestrin1在骨骼肌高表达；Sestrin2在脂肪高表达。(b) SAR1B区别于CopII其他亚基单独在骨骼肌高表达。(c, d) 肌肉和脂肪细胞中亮氨酸感知的差异。(e) SAR1B和Sestrin协同调控mTOR...
SAR1B的经典功能是作为小G蛋白酶参与囊泡形成,并与其他四个亚基共同组装成COPII复合物,在内质网向高尔基体递送物质的过程中发挥重要作用。但SAR1B感知亮氨酸的过程并不依赖于其经典的小G蛋白酶活性。 亮氨酸缺乏时,SAR1B通过靶向作用mTORC1的激活物GATOR2,抑制mTORC1信号;亮氨酸充足时,SAR1B与亮氨酸直接结合,...
研究人员结合免疫共沉淀和质谱技术鉴定到亮氨酸受体蛋白SAR1B。SAR1B的经典功能是作为小G蛋白酶参与囊泡形成,并与其他四个亚基共同组装成COPII复合物,在内质网向高尔基体递送物质的过程中发挥重要作用【4】。研究人员发现,SAR1B感知亮氨...
研究人员结合免疫共沉淀和质谱技术鉴定到亮氨酸受体蛋白SAR1B。SAR1B的经典功能是作为小G蛋白酶参与囊泡形成,并与其他四个亚基共同组装成COPII复合物,在内质网向高尔基体递送物质的过程中发挥重要作用【4】。研究人员发现,SAR1B感知亮氨酸的过程并不依赖于其经典的小G蛋白酶活性。 体外实验表明,SAR1B能够直接结合...
COPII and the regulation of protein sorting in mammals. Nat. Cell Biol. 14, 20–28 (2012) 本文由“健康号”用户上传、授权发布,以上内容(含文字、图片、视频)不代表健康界立场。“健康号”系信息发布平台,仅提供信息存储服务,如有转载、侵权等任何问题,请联系健康界(jkh@hmkx.cn)处理。 关键词: ...
3. Wolfson, R. L. et al. Sestrin2 is a leucine sensor for the mTORC1 pathway.Science351,43–48 (2016) 4. Zanetti, G., Pahuja, K. B., Studer, S., Shim, S. & Schekman, R.. COPII and the regulation o...
The protein encoded by this gene is a small GTPase that acts as a homodimer. The encoded protein is activated by the guanine nucleotide exchange factor PREB and is involved in protein transport from the endoplasmic reticulum to the Golgi. This protein is part of the COPII coat complex. Defect...
A key component of COPII is small GTPase Sar1. Five Sar1 isoforms are encoded in the Arabidopsis genome and they show distinct while redundant roles in various cellular and developmental processes, especially in reproduction. Arabidopsis Sar1b is essential for sporophytic control of pollen ...
It is involved in transport from the endoplasmic reticulum to the Golgi apparatus. SAR1B is activated by the guanine nucleotide exchange factor PREB. It is involved in the selection of the protein cargo and the assembly of the COPII coat complex....
Mouse Anti Human Monoclonal. Introduction SAR1B is a small GTPase that functions as a homodimer. GTP-Binding Protein SAR1B (SAR1b) is involved in transport from the endoplasmic reticulum to the Golgi apparatus and also in the selection of the protein cargo and the assembly of the COPII coat...