Using purified, bacterially expressed proteins we demonstrate that the product of AN11127 accelerates nucleotide exchange on SarA(SAR1), but not on its closely related GTPase ArfA(ARF1), as expected for a bona fide GEF. The unequivocal characterization of A. nidulans Sec12 paves the way for ...
Abbreviations—The abbreviations used are: COPII coat protein complex II CMRD chylomicron retention disease GEF guanine exchange factor af GTPase activating fragment GTPa GTP-adjacent ER endoplasmic reticulum GMP-PNP 5′-Guanylyl imidodiphosphate. ...
Viktorova, E.G.; Gabaglio, S.; Meissner, J.M.; Lee, E.; Moghimi, S.; Sztul, E.; Belov, G.A. A Redundant Mechanism of Recruitment Underlies the Remarkable Plasticity of the Requirement of Poliovirus Replication for the Cellular ArfGEF GBF1.J. Virol.2019,93, e00856-19. [Google ...
ARF1 is present in its GDP form in the cytosol and is recruited to the surface of Golgi membranes by a GEF. A SEC7-type GEF promotes the binding of GTP to ARF1. This process can be inhibited by the fungal metabolite Brefeldin A (BFA) in mammalian cells [30]. In animal cells, the...
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Using purified, bacterially expressed proteins we demonstrate that the product of AN11127 accelerates nucleotide exchange on SarASAR1, but not on its closely related GTPase ArfAARF1, as expected for a bona fide GEF. The unequivocal characterization of A. nidulans Sec12 paves the way for the ...
The active GTP-bound state is regulated by guanine nucleotide exchange factors (GEF), which promote the exchange of GDP for GTP. The inactive GDP-bound state is promoted by GTPase-activating proteins (GAPs) which accelerate GTP hydrolysis by orders of magnitude. Two types of small GTP-binding ...
Memon AR: The role of ADP-ribosylation factor and SAR1 in vesicular trafficking in plants. Biochim Biophys Acta 2004, 1664:9 -30Erratum to “The role of ADP-ribosylation factor and SAR1 in vesicular trafficking in plants”[J] . Abdul R. Memon.BBA - Biomembranes . 2004 (1)...