SAR-by-NMRSynonymsSynonymsLead discovery by NMR; NMR-screeningDefinitionDefinitionNMR can be used as a method for monitoring protein-ligand interactions, either by detecting protein signals or the signals of thdoi:10.1007/978-3-540-38918-7_154Hartmut Oschkinat...
Drug Development: BOC-SAR-OH is also utilized in drug development processes. It can be used as a building block for the synthesis of various pharmaceutical compounds. Its mechanism of action in this context depends on the specific drug being developed, as BOC-SAR-OH serves as a precursor for...
The purity of all synthesized compounds were >98% determined by HPLC. Structural confirmation of 23 was based on its NMR, mass spectra and elemental analysis. In the 1H NMR we observed only three signals related to three hydrogens which indicated a probable bi-nitration. There were two ...
Reverse transcriptase (RT) is one of the main targets for antiretroviral drug development due to its essential role in the HIV replication. HIV uses its RT to convert its RNA genome into DNA. Thus, inhibition of this activity impedes HIV's ability to replicate and to infect additional cells....
MethodCell growth inhibition activity is determined in a water-soluble tetrazolium-based assay. Cell death is measured by trypan blue staining and apoptosis is determined using an Annexin V-FLUOS staining kit. In Vivo In vivoIn the SJSA-1 osteosarcoma, acute lymphoblastic leukemia RS4;11, LNCaP ...
Conformations of the cyclic tetrapeptide cyclo(L-Pro-Sar)2 in solution were studied by 1H- and 13C-nmr spectrometry and model building. The nmr data provide definite evidence that this cyclic peptide exists chiefly in two conformations, namely, a C2-symmetric conformation and an asymmetric ...
Additionally, obtained compounds screened for their antioxidant actions by using H2O2, DPPH and NO methods. Most of the compounds delivered high to moderate free radical scavenging activity. In addition, the IC50 results of biologically active compounds and mechanism of free radical action are also ...
Check access to the full text by signing in through your organization. Access through your organization Section snippets Acknowledgements The authors are grateful to Jennifer Van Anda and the purification group for SFC separation of chiral sulfoxides, James Hall for NMR support, Donald Pivonka and...
Conformations of the cyclic tetrapeptide cyclo(L-Pro-Sar)2 in solution were studied by 1H- and 13C-nmr spectrometry and model building. The nmr data provide definite evidence that this cyclic peptide exists chiefly in two conformations, namely, a C2-symmetric conformation and an asymmetric ...
Since this enzyme is implicated in important biological processes, such as cellular detoxification and drug-resistance, the molecular dynamics and functional properties of this enzyme are of great interest. NMR methods were applied to study the dynamic properties of hGSTA1-1. Backbone assignments were...